摘要
目的探讨消化道颗粒细胞瘤(granular cell tumor,GCT)的临床病理特点、诊断及鉴别诊断。方法对12例消化道GCT进行临床资料分析,病理形态观察及免疫组织化学检测。结果 12例消化道GCT形态相似,肿瘤细胞多呈巢状和片状排列,瘤细胞体积大,形态单一,多边形或梭形,胞质丰富,嗜酸性颗粒状。免疫组化显示肿瘤细胞呈S-100和vimentin弥漫阳性;CD68散在阳性;而上皮细胞标记EMA、CK(AE1/AE3)呈阴性。结论消化道GCT是一种少见的神经源性肿瘤,多为偶然发现,内镜和形态学上容易误诊,免疫组化对鉴别诊断有重要意义。
Purpose To discuss the clinicopathologic features and differential diagnosis of granular cell tumors（GCT） of the digestive tract.Methods Twelve cases of digestive tract GCT were investigated pathologically and immunohistochemically.Results Microscopically,the tumor cells of digestive tract GCT were arranged in nests or sheets.The tumor cells were big in size and uniform in shape and full of abundant eosinophilic cytoplasm.Immunohistochemically,the tumor cells were positive for S-100,vimentin and CD68,while AE1/AE3 and EMA were negative.Conclusions Digestive tract GCT is a rare tumor originated from schwann cell.Most of them are benign and found by endoscopy occasionally.But the GCT is easily misdiagnosed and the immunohistochemistry is of great importance in the differential diagnoses.
出处
《临床与实验病理学杂志》
CAS
CSCD
北大核心
2010年第3期305-307,311,共4页
Chinese Journal of Clinical and Experimental Pathology
关键词
颗粒细胞瘤
消化系统肿瘤
免疫组织化学
鉴别诊断
granular cell tumors
digestive system neoplasms
immunohistochemistry
differential diagnosis
