摘要
目的：探讨孟鲁司特钠治疗儿童咳嗽变异性哮喘的临床疗效。方法：将60例咳嗽变异性哮喘患儿随机分为两组，对照组30例给予口服丙卡特罗和异丙嗪；治疗组30例患儿在对照组基础上加用孟鲁司特钠口服，比较两组的疗效。结果：治疗组显效率66．7％（20／30），治疗显效者在（2．7±1．2）d症状得到缓解，（4．8±1．5）d后症状完全消失；总有效率96．7％；和对照组比较有显著性差异（P〈0．05）。两组患儿用药后不良反应差异没有显著性（P〉0．05）。结论：孟鲁司特钠治疗小儿咳嗽变异性哮喘临床疗效肯定、不良反应少，依从性好，值得临床推广应用。
Objective： To investigate the effect of montelukast sodium in treatment of children with cough variant asthma. Methods： 60 patients with cough variant asthma were randomly divided into two group, 30 patients as control group were gave oral procaterol and promethazine; 30 patients as treatment group were oral montelukast sodium based on the treatment of control group, and the efficacy was compared. Results： The markedly effec- tive rate in the treatment group was 66.7% （20/30） with the symptoms reduced in （2.7±1.2） days and symptoms disappeared in （4.8±1.5） days. Total effective rate was 96.7%t; compared with control group, the different were significantly （P（0. 05）. Adverse reactions between two groups, there was no significant difference （P〉0.05）. Conclusion： Using Montelukast in treatment of children with cough variant asthma, the effect was good and adverse reaction was less. It is worthy of clinical application.
关键词
儿童咳嗽变异性哮喘
孟鲁司特钠
白三烯
疗效
children with cough variant asthma
montelukast sodium
leukotriene
effect
