摘要
以四氯苯酐为原料，经酰亚胺化，氟化，水解得四氟邻苯二甲酸，该合成路线工艺简单、反应条件温和，总收率提高到７９％
A facile preparation of tetrafluorophthalic acid starting from tetrachlorophthalic anhydride via imidation,fluorination and hydrolysis was described.The reactions of all the steps were carried out in moderate conditions to afford an overall yield of 79%.
出处
《中国药物化学杂志》
CAS
CSCD
1999年第1期53-55,共3页
Chinese Journal of Medicinal Chemistry
关键词
四氟邻苯二甲酸
中间体
合成
工艺
tetrafluorophthalic acid
intermediate for pharmaceuticals
synthesis
