摘要
目的探讨血、尿β2-微球蛋白(β2-MG)对新生儿高疸红素血症患儿早期肾功能损害的变化和意义。方法采用反射比浊法测定62例新生儿高疸红素血症患儿(研究组)及23例正常足月新生儿(对照组)的血、尿β2-MG含量水平进行检测。结果高疸红素血症患儿血、尿β2-MG含量与血清胆红素含量之间有一定的依从关系(r血=0.529,P<0.01,r尿=0.359,P<0.01)。当血疸红素水平在91-205μmol/L时,血β2-MG的含量比正常对照组升高,差别有显著意义(P<0.5),而尿β2-MG较对照组,稍高(P>0.05)无显著意义。当血清胆红素在205.2-256.5μmol/L时,血、尿β2-微球蛋白(β2-MG)含量均较对照组明显升高(P<0.05),当血清总胆红素≥256.5μmol/L时血、尿β2-微球蛋白(β2-MG)的含量较对照组显著升高(P<0.001)。结论新生儿高疸红素血症患儿早期存在肾功能损害,检测血、尿β2-微球蛋白(β2-MG)的浓度是观察肾小球滤过和肾小管重吸收功能的特异性指标,但血β2-微球蛋白(β2-MG)更能早期敏感地判断新生儿黄疸时对肾脏的损害。
Objective：To value the change and meaning of β2-MG in blood and urine in neonatal hperbilirubinemia infants with earier period renal functional lesion.Methods：Collect 62 neonatal infants with hyperbilirubinemia and 23 nomal term infants,and test the β2-MG in blood and urine by reflect turbidity method. Results：（1） In the group of infants with serum bilirubin content ranged from 171 to 205 μmol/L,β2-MG in blood is higher than it in control group,and the difference between two groups was significant. While β2-MG in urine was little higer,and the difference was no significant（P〉0.05）. When the serum bilirubin content was higher than 256.6 μmol/L,the content of β2-MG in blood and urine in experiment group was both higher than it in control group,the difference between two groups was significant. （2） There is some relation between the serum total bilirubin content and β2-MG in blood and urine（P〈0.01）.Conclution：β2-MG in urine could be a,useful index to diagnose earlier period renal functional lesion in neonatal hyperbilirubinemia infants.
出处
《中国优生与遗传杂志》
2010年第7期77-78,共2页
Chinese Journal of Birth Health & Heredity
