期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

PUMA作为细胞保护和肿瘤治疗靶点的研究进展 被引量：3

PUMA: a new target in cytoprotective and tumor therapy
原文传递
导出
摘要 PUMA(p53 up-regulated modulator of apoptosis)是Bcl-2蛋白家族的促凋亡成员之一,具有强大的促凋亡作用。研究发现PUMA表达水平的降低与肿瘤的发生密切相关,上调PUMA在肿瘤细胞中的表达可以增强肿瘤细胞对放化疗的敏感性。PUMA的缺失可以有效降低由放、化疗引起的正常组织损伤。该文简要综述了PUMA在肿瘤治疗以及在放化疗引起的正常组织损伤中的作用进展。 PUMA （p53 upregulated modulator of apoptosis） is a member of the Bcl-2 family and plays a powerful pro-apoptotic role. The studies showed that the decrease of PUMA expression was closely related to the occurrence of tumor and upregulation of PUMA expression could enhance tumor sensitivity to radiotherapy and chemotherapy. The deletion of PUMA could effectively reduce the damage of radiotherapy and chemotherapy to normal tissues. Here we review the research progress of PUMA as a therapeutic target in cancer treatment and cytoprotection.
作者 周长辉 关方霞 常建辉 孟爱民
机构地区 郑州大学生物工程系 中国医学科学院放射医学研究所
出处 《生命科学》 CSCD 北大核心 2010年第6期556-560,共5页 Chinese Bulletin of Life Sciences
基金 国家自然科学基金资助项目(30770645) 天津市自然科学基金(08JCYBJC07300) 教育部新教师基金课题(20070023102) 教育部新世纪优秀人才支持项目计划资助(2006NECT060610)
关键词 PUMA 肿瘤 干细胞 靶点 细胞保护 PUMA tumor stem cell therapy target cytoprotective effect
分类号 R730.59 [医药卫生—肿瘤]
  • 相关文献

参考文献37

  • 1赵宝锋,刘建香,苏旭.细胞凋亡信号通路调控与肿瘤辐射敏感性[J].中华放射医学与防护杂志,2005,25(4):401-404. 被引量：15
  • 2Adams JM, Cory S. The Bcl-2 apoptotic switch in cancer development and therapy. Oncogene, 2007, 26(9): 1324-37.
  • 3Yu J, Wang Z, Kinzler KW, et al. PUMA mediates the apoptotic response to p53 in colorectal cancer cells. Proc Natl Acad Sci USA, 2003, 100 (4): 1931.
  • 4Niizuma K, Endo H, Nito C, et al. Potential role of PUMA in delayed death of hippocampal CA1 neurons after transient global cerebral ischemia. Stroke, 2009, 40(2): 618-25.
  • 5Avila JL, Grundmann O, Burd R, et al. Radiation-induced salivary gland dysfunction results from p53-dependent apoptosis. Int J Radiat Oncol Biol Phys, 2009, 73(2): 523-9.
  • 6Nakano K, Vousden KH. PUMA, a novel proapoptotic gene, is induced by p53. Mol Cell, 2001, 7(3): 683-94.
  • 7You H, et al. FOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawal. J Exp Med, 2006, 203:1657-63.
  • 8Lain D, Dickens D, Reid EB,et al. MAP4K3 modulates cell death via the post-transcriptional regulation of BH3-only proteins. Proc Natl Acad Sci USA, 2009, 106(29): 11978-83.
  • 9Chipuk JE, Bouchier-Hayes L, Kuwana T, et al. PUMA couples the nuclear and cytoplasmic proapoptotic function of p53. Science, 2005, 309(5741 ): 1732-5.
  • 10Ming, L, Wang P, Bank A, et al. PUMA dissociates Bax and BCL-XL to induce apoptosis in colon cancer cells. J Biol Chem, 2006, 281; 16034-42.

二级参考文献37

  • 1Rodel C, Haas J, Groth A, et al. Spontaneous and radiation-induced apoptosis in colorectal carcinoma cells with different intrinsic radiosensitivities : Survivin as a radioresistance factor, Int J Radiat Oncol Biol Phys, 2003, 55 : 1341-1347.
  • 2Sakakura C, Sweeney EA, Shirabama T, et al. Overexpression of bax enhances the radiation sensitivity in human breast cancer cells. Surg Today, 1997, 27: 90-93.
  • 3Kim R, lnoue H, Toge T. Bax is an important determinant for radiation sensitivity in esophageal carcinoma cells, lnt J Mol Med, 2004, 14:697-706.
  • 4Morgan MA, Poynter JN, Maybaum J, et al. The role of Bcl-Xs in radiation sensitivity. Radiat Res, 2004, 161:535-539.
  • 5Scott SL, Higdon R, Beckett L, et al. Bcl2 antisense reduces prostate cancer cell survival following irradiation. Biother Radiopharm, 2002,17 : 647-656.
  • 6Lu B, Mu Y, Cao C, et al. Survivin as a therapeutic target for radiation sensitization in lung cancer. Cancer Res, 2004, 64:2840-2845.
  • 7Pennati M, Binda M. Radiosensitization of human melanoma cells by ribozyme-mediated inhibition of survivin expression. J Invest Dermatol,2003, 120:648-654.
  • 8Du C, Fang M, Li Y, et al. Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell, 2000, 102: 33-42.
  • 9Shinomiya N. New concepts in radiation-induced apoptosis: ' premitotic apoptosis ' and 'postmitotlc apoptosis '. J Cell Mol Med, 2001, 5:240-253.
  • 10Schulze-Bergkamen H, Krammer PH. Apoptosis in cancer-implications for therapy. Semin Oncol, 2004, 31:90-119.

共引文献16

同被引文献24

  • 1卫菊,王椿.从BCL-2凋亡抑制因子家族的调控中寻找癌症治疗的新途径[J].世界临床药物,2006,27(5):270-273. 被引量：3
  • 2张宇雯,刘兴汉.唯BH3域蛋白与细胞凋亡[J].医学分子生物学杂志,2007,4(2):143-146. 被引量：4
  • 3张文毅,詹辉,王剑松.凋亡素诱导肿瘤细胞凋亡机制研究及其进展[J].临床泌尿外科杂志,2007,22(7):551-553. 被引量：1
  • 4Litvak DA,Bilcbik AF,Cabot MC.Modulators of ceramide metabolism sensitize colorectal cancer cells to chemotherapy:A novel treatment strategy[J].J Gastrointest Surg,2003,7(12):140-148.
  • 5Dharap SS,Qiu B,Williams GC.Molecular targeting of drug delivery systems to ovarian cancer by BH3 and LHRH peptides[J].Journal of Controlled Release,2003,91(10):61-73.
  • 6Liu JW,Chandra D,Tang SH,et al.Identification and characterization of Bimgamma,a novel proapoptotic BH3-only splice variant of Bim[J].Cancer Res,2002,62(10):2976-2981.
  • 7Petros AM,ET Olejniczak,SW Fesik.Structural biology of the Bcl-2 family of proteins[J].Biochim Biophys Acta,2004,1644(2-3):83-94.
  • 8Lutz R.J.Role of the BH3 (Bcl-2 homology 3) domain in the regulation of apoptosis and Bcl-2-related proteins[J].Biochem Soc Trans,2000,28(2):51-56.
  • 9蔡应木,张俏忻,肖颖秀,焦晓阳.2-甲氧雌二醇对HL60白血病细胞增殖和凋亡的影响[J].国际检验医学杂志,2007,28(11):961-963. 被引量：5
  • 10Nathan P. Gomes,Joaquin M. Espinosa.Gene-specific repression of the p53 target gene PUMA via intragenic CTCF-Cohesin binding. Genes and Development . 2010

引证文献3

二级引证文献3

生命科学
2010年 第6期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部