摘要
目的评价他汀类药物对糖尿病肾病尿蛋白的影响。方法调查国内外他汀类药物影响糖尿病肾病尿蛋白的研究,对23项随机对照实验(共1789例患者)进行Meta分析。结果采用随机效应模型对24h尿蛋白进行比较:χ2=54.97,加权均数差=-0.79[-1.51,-0.06];采用随机效应模型对早期糖尿病肾病24h尿蛋白进行比较:χ2=7251.14,加权均数差=-38.55[-65.25,-11.85];采用固定效应模型对临床期糖尿病肾病24h尿蛋白进行比较:χ2=0.99,加权均数差=-70.49[-99.72,-41.27];报道的不良反应44例。结论他汀类药物能降低糖尿病肾病患者的病理性尿蛋白及尿白蛋白,但是否对终末期肾病有效,还取决于能在多大程度上改善尿蛋白的排泄,仍需要大量的大规模多中心随机临床对照试验来加以证明。
Objectives To evaluate the effect of statins on albuminuria in patients with diabetes-induced renal diseases. Methods All the papers of randomized controlled trials evaluating the effects of statins on diabetes-induced renal diseases in China and abroad were investigated. Meta-analysis was performed on the basis of the evaluation of 23 trails of randomized controlled trials （ineluding 1 789 patients）. Results The proteinuria excretion measured by 24 h urine collection was compared by random effect mode ：X^2 =54.97, weight mean difference （WMD） =-0.79 [-1.51, -0.06 ] ; Albuminuria excretion measured by 24 h urine collection in the early stage was compared by random effect model： X^2= 7251.14, WMD=-38.55 [-65.25,-11.85]; Albuminuria excretion measured by 24 h urine collection in the clinical stage was compared by fixed effect model： X^2=0.99, WMD=-70.49 [-99.72,-41.27 ];reported adverse reactions were 44 patients. Conclusions Statins have a beneficial effect on pathological proteinuria and the albuminuria in the diabetes-induced renal diseases. The validity of this finding requires supports by more studies of larger size to evaluate the effect on endstage of the diseases.
出处
《岭南心血管病杂志》
2010年第3期214-218,共5页
South China Journal of Cardiovascular Diseases
