摘要
目的探讨催产素对硬膜外阻滞患者血流动力学的影响。方法择期子宫肌瘤剔除术患者26例,随机分为硬膜外阻滞组(E组)与全身麻醉组(G组),每组13例。E组采用2%利多卡因硬膜外阻滞,阻滞平面上界T6～T8;G组全身麻醉用丙泊酚、芬太尼、雷米芬太尼、维库溴铵和异氟醚。两组子宫肌瘤剔除后、血流动力学稳定时静注催产素5U(注射时间:30s)。记录催产素注射前、注射后MAP、HR。结果两组注射催产素后MAP均显著下降、HR显著增快(P<0.05或P<0.01);E组MAP下降幅度明显大于G组,持续时间明显长于G组,E组HR增快程度明显小于G组,持续时间明显短于G组(P<0.05或P<0.01)。结论硬膜外阻滞可加重催产素降低血压的副作用,同时可抑制催产素引起的心率增快作用。
Objective To investigate the effects of oxytocin on hemodynamics in patients under epidural block.Methods Twenty-six selective myomectomy patients were randomly divided into epidural block group（E） and general anesthesia group（G） with 13 cases each.Epidural anesthesia with 2% lidocaine was performed with the blocking plane of T6-T8.Group G was given general anesthesia with propofol,fentanyl,remifentanyl and vecuronium.Oxytocin 5 U was injected in 30 s when hysteromyoma was removed and the hemodynamics was stable.MAP and HR were recorded before and after oxytocin injection.Results Compared to those before,MAP was decreased and HR was increased after oxytocin injection in both groups（P〈0.05 or P〈0.01）.The decrease of MAP was slower but lasted for a longer period in group E than those in group G（P〈0.05 or P〈0.01）.Conclusion Epidural blockade may aggravate the hypotensive effect of oxytocin and inhibit oxytocin-induced HR increasise.
出处
《临床麻醉学杂志》
CAS
CSCD
北大核心
2010年第3期212-214,共3页
Journal of Clinical Anesthesiology
