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SLE患者淋巴和单核细胞体积、浆核复杂性的变化及临床意义

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摘要 目的探讨系统性红斑狼疮(SLE)患者淋巴细胞与单核细胞体积、浆核复杂性的变化情况及其临床意义。方法利用Beckman-Coulter Gen.S全自动血细胞分析仪的体积、高频传导、激光散射(VCS)技术,测定62例SLE患者及69例健康正常人的淋巴细胞体积(LYV),浆核比(LYC),激光散射强度(LYS)及它们各自的平均分布宽度(SD),以及单核细胞体积(MOV),浆核比(MOC),激光散射强度(MOS)及它们各自的平均分布宽度(SD),并进行比较分析。结果与正常对照组比较,SLE患者LYV、LYV-SD、MOV、MOV-SD均显著增大(P<0.05或P<0.01);LYC、MOC、LYS、MOS、MOS-SD均明显变小(P<0.01),而LYC-SD明显增大(P<0.01),MOC-SD及LYS-SD无统计学差异(P>0.05)。结论SLE患者淋巴与单核细胞的VCS各参数(除MOC-SD及LYS-SD外)均发生一定程度的变化;淋巴和单核细胞VCS参数的检测可作为SLE患者诊断和治疗的辅助实验室指标。
出处 《浙江实用医学》 2010年第3期229-229,247,共2页 Zhejiang Practical Medicine
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