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Keap1在氧化应激方面的研究进展 被引量：17

Progress in study on relationship of Keap1 with oxidative stress
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摘要 外界环境的刺激会破坏生物体内的氧化还原平衡,产生氧化应激。为了应对氧化应激产生的毒性作用,体内细胞在进化过程中产生了复杂的机制来应对氧化应激,Keap1(Kelch-like Ech-associated protein-1)是抗氧化应答机制中最重要的分子之一。本文从Keap1的克隆和表达、定位及结构以及功能方面对Keap1在生物体内应对氧化应激所起的作用进行了综述。 Exogenous chemical insults can cause severe damage to the redox homeostasis of biomolecules and lead to oxidative stress reaction. In order to consult these toxicant reaction,eukaryotic cells have evolved complex defense mechanisms to cope with toxicant-induced oxidative stress. One of the most important cellular defense mechanisms against oxidative stress is mediated by the transcription factor Nrf2 and its parter Keap1. This article reviewed the clone,expression,location,structure and function of Keap1 and highlight the importance of Keap1 as a molecular target for disease prevention.
作者 刘芳 杜志银 王应雄
机构地区 重庆市江北区第一人民医院检验科 重庆医科大学信息管理系 重庆医科大学基础医学院
出处 《中国临床药理学与治疗学》 CAS CSCD 2010年第5期596-600,共5页 Chinese Journal of Clinical Pharmacology and Therapeutics
关键词 KEAP1 氧化应激 NRF2 Keap1 Oxidative stress Nrf2
分类号 R994 [医药卫生—毒理学]
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参考文献21

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二级参考文献41

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共引文献22

同被引文献265

引证文献17

二级引证文献107

中国临床药理学与治疗学
2010年 第5期

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