摘要
目的:探讨联合用药治疗原发性高血压的临床效果。方法:将我院高血压病患者60例随机分为A、B、C组,A组单纯给予硝苯地平缓释片治疗,B组给予硝苯地平缓释片联合贝那普利片治疗,C组给予硝苯地平缓释片联合依那普利片治疗,随访观察治疗效果。结果:治疗后B、C组收缩压及舒张压均优于A组,两者分别比较差异具有统计学意义(P<0.05)。B组收缩压及舒张压与C组比较差异无统计学意义(P>0.05)。治疗后B、C组总有效率均为95%,A组总有效率为70.00%,B、C组总有效率均高于A组,两者分别比较差异具有统计学意义(P<0.05);B组总有效率与C组比较差异无统计学意义(P>0.05)。三组均未见明显的治疗副作用。结论:联合用药治疗原发性高血压病疗效好于单一用药,且硝苯地平缓释片联合贝那普利与联合依那普利治疗原发性高血压病疗效相当。
Objective：To investigate the effect of drug combination of antihypertensive agent in treating hypertension.Method： The 60 cases with hypertension were divided into the A,B and C group.The A group received the treatment of extended release nifedipine tablets,the B group received the treatment of extended release nifedipine tablets combined with benazepril hydrochloride tablets,and the C group received the treatment of extended release nifedipine tablets combined with enalapril maleate tablets.All of them were followed-up.Result： The contractive pressure and diastolic blood pressure of B and C group were superior to those in A group,and there were significant difference in them respectively（P0.05）.The contractive pressure and diastolic blood pressure of B group were the same to those in C group,and there were no significant difference in them respectively（P0.05）.The total rate was 95% in the B and C group and 70.00% in the C group.The total rate of B and C group were superior to those in A group,and there were significant difference in them respectively（P0.05）.The total rate of B group were the same to those in C group,and there were no significant difference in them respectively（P0.05）.There was no significant side reaction in them.Conclusion： The effect of drug combination in treating hypertension is superior to the singal drug,and the effect of extended release nifedipine tablets combined with benazepril hydrochloride tablets were same to extended release nifedipine tablets combined with enalapril maleate tablets.
出处
《河北医学》
CAS
2010年第7期835-837,共3页
Hebei Medicine
