摘要
目的为了探索骨髓血甲胎蛋白（ＡＦＰ）检测对原发性肝细胞癌的诊断价值。方法选择经病理和／或手术确诊的肝细胞癌患者２９例。采取患者骨髓血和静脉血，用放射免疫法测定其ＡＦＰ含量，并与临床病理资料进行配对统计学分析。结果骨髓血ＡＦＰ的含量为４３６４±９６５μｇ／Ｌ，血清ＡＦＰ含量为４１０１±９１０μｇ／Ｌ，两者对肝细胞癌的诊断阳性率均为５５２％（１６／２９）。两者无显著性差异（Ｐ＞０．０５）。伴有门静脉癌栓、肝门淋巴结转移、骨转移者与其相对应组比较仍无显著性差异。结论骨髓血与外周静脉血对肝细胞肝癌的诊断具有同样价值，因其采集较静脉血困难，不宜作为常规检测方法。
Objective To explore the diagnostic value of alpha fetoprotein (AFP) in bone marrow blood in patients with primary hepatocellular carcinoma (PHCC). Methods AFP concentration in bone marrow blood and in peripheral vein blood in 29 patients with PHCC confirmed by operation and/or pathology was detected respectively by radioimmuoassay. Results The level of AFP in bone marrow blood was 436.4±96.5μg/L, while the level of AFP in peripheral vein blood was 410.1±91.0μg/L ( P >0.05). There was no significant difference of the AFP level in different materia even in patients with portal vein embolism, lympha metastasis or bone metastasis. Conclusions The diagnostic value of AFP in bone marrow blood as much as that in peripheral vein blood. It suggests that the detection of AFP in bone marrow blood be not widely used in the patients with PHCC, because the collection of blood from bone marrow is more difficulty than that from peripheral vein blood.
出处
《中国普通外科杂志》
CAS
CSCD
1999年第2期98-100,共3页
China Journal of General Surgery
