摘要
目的：探讨Ｂｃｌ－２蛋白在子宫内膜癌组织中的表达及其临床意义。方法：应用免疫组化法测定对５０份子宫内膜癌石蜡包埋标本Ｂｃｌ－２蛋白的表达。结果：Ｂｃｌ－２蛋白在子宫内膜癌组织中的表达阳性率为４８．００％（２４／５０），其阳性表达与子宫内膜癌的组织学分级、肌层浸润深度及患者预后有关（Ｐ＜０．０５），与子宫内膜癌临床分期、组织学类型及病理学类型无关。结论：Ｂｃｌ－２蛋白表达与子宫内膜癌的某些病理学特征及生物学行为之间有相关性。应用免疫组化法测定Ｂｃｌ－２蛋白表达对判断子宫内膜癌患者的预后有一定的价值。
Objective:To study the expression of Bcl 2 protein in endometrial carcinoma(EC)and its clinical significance.Methods:Formalin fixed paraffin embedded specimens from 50 patients with EC were studied.Bcl 2 protein was detected by immunohistochemical assay using monoclonal antibody.Results:The expression of Bcl 2 protein was found in 24/50(48.00%)of EC.The positive rate of Bcl 2 expression in patients with EC was significantly related to carcinoma cell grade,depth of myometrium invasion and patients prognosis(P<0.05).It was not related to the tissue type,clinical stage and growth type of carcinoma.Conclusions:The expression of Bcl 2 protein is correlated with some pathological characteristics and the biological behavior of EC.The study of expression of Bcl 2 protein using immunohistochemical assay is helpful in evaluating the prognoses of patients with EC.
出处
《现代妇产科进展》
CSCD
1999年第1期25-27,共3页
Progress in Obstetrics and Gynecology
