摘要
目的探讨超声造影对移植肝内局灶性病变的鉴别诊断价值。方法对67例肝移植术后确诊有移植肝内局灶性病变的患者进行超声造影检查,观察不同病变在动脉期、门静脉期和延迟期3个时相的造影剂灌注模式。以延迟期仍保持高增强或等增强或造影中始终无增强判定为良性病变,以延迟期消退为低增强或无增强判定为恶性病变,计算超声造影诊断良性病变与恶性病变的敏感度与假阴性率。结果与良性病变比较,在动脉期表现为高增强或等增强的病灶中,恶性病变在门静脉期或延迟期有显著的增强消退倾向(P<0.01)。超声造影诊断良性病变的敏感度为90%(19/21),假阴性率为10%(2/21),2例假阴性均为肝脓肿;诊断恶性病变的敏感度为100%(46/46)。结论超声造影对移植肝内局灶性病变具有较高的鉴别诊断价值,有助于区别良、恶性病变。
Objective To explore the diagnostic value of contrast-enhanced ultrasound （CEUS） in the focal liver lesions after liver transplantation. Methods Sixty-seven patients with focal liver lesions after liver transplantation were examined by CEUS. The infusion patterns of contrast agent were observed in arterial, portal-venous and late phases. The manifestations of persistent enhancement in late phase or never enhancing in all phases were considered as benign lesion while presenting lowor non-enhancement in late phase were considered as malignant lesion. Sensitivity and false negative rate of CEUS for the differential diagnosis of benign and malignant lesions were calculated. Results In the lesions with hyper-enhancement during arterial phase, the enhancement of malignant lesions were more likely to subside during portal-venous and late phases compared with benign lesions （P 〈0. 01 ）. The sensitivity of estimation of benign lesions by CEUS was 90% （ 19/21 ） with a false negative rate of 10% （2/21）. Two false negative cases were liver abscesses. The sensitivity of estimation of malignant lesions was 100% （46/46）. Conclusion CEUS has high diagnostic value in the focal liver lesions after liver transplantation and is helpful in differentiating between malignant and benign lesions.
出处
《器官移植》
CAS
2010年第4期204-207,共4页
Organ Transplantation
基金
卫生部公益性行业科研专项基金(2007-2-10)
关键词
超声造影
肝移植
局灶性病变
鉴别诊断
Contrast-enhanced ultrasound
Liver transplantation
Focal liver lesion
Differential diagnosis
