摘要
目的:观察胸腺肽α1联合拉米夫定对慢性乙型肝炎(CHB)患者Th1/Th2类细胞因子表达的影响。方法:将慢性乙型肝炎患者48例,分为治疗组24例和对照组24例,采用双抗体夹心酶联免疫吸附法检测两组Th1类细胞因子γ-干扰素(IFN-γ)和Th2类细胞因子白介素-4(IL-4),HBV-DNA水平并比较治疗前、后变化。结果:治疗组和对照组在治疗后6个月乏力、纳差、肝区不适等症状、体征均有所改善,但治疗组改善情况优于对照组,总有效率(95.8%,23/24)明显高于对照组(75.0%,18/24)(P<0.01)。对照组治疗前后各指标差异均无统计学意义(P>0.05);治疗组治疗后IL-4,HBV-DNA水平较治疗前及对照组治疗后明显降低(P<0.01),IFN-γ水平明显升高(P<0.01)。结论:胸腺肽α1能明显提高慢性乙型肝炎患者的Th1类细胞因子中IFN-γ表达水平,改善患者Th1/Th2细胞功能失衡状态,有利于病毒的清除。
Objective：To observe the effect of Thymic Peptide α1 combine with Lamivudine on levels of Th1/Th2-like cytokine in chronic hepatitis type B patients.Methods：A total of 48 cases with chronic hepatitis type B were divided into the treatment group and the control group by half.The levels of Th1-like cytokine（IFN-γ）,Th2-like cytokine（IL-4）and HBV-DNA were tested by quantitative enzyme-linked sandwich immunoassay method.Meanwhile,the changes were compared before and after the treatment.Results：Symptoms and signs in both group changed after treatment in 6 months including lack of power,poor appetite and liver was uncomfortable.But the condition of treatment group was better than control gourp.The total effective rate in treatment group（95.8%,23/24）was higher then control group（75.0%,18/24）（P〈0.01）.The indications before and after the treatment in the control group was not significantly different（P〉0.05）.IL-4 and HBV-DNA level after treated in treatment group were significantly lower th...更多an before as well as compared with treated cases in the control group.The level of IFN-γ was increased obviously（P〈0.01）.Conclusions：Thymic Peptide α1 can obviously improve the expressed level of IFN-γ among Th1-like cytokine in chronic hepatitis type B patients.It can improve the unbalance condition between Th1/Th2 cells and benefit for cleaning virus.
出处
《海南医学院学报》
CAS
2010年第7期856-858,共3页
Journal of Hainan Medical University
基金
海南医学院科研基金资助学报项目(0020100236)~~
