摘要
目的探讨同型半胱氨酸(Hcy)和超敏C-反应蛋白(hs-CRP)的血清水平在监测冠心病病情方面的作用及与冠状动脉病变程度的关系。方法冠心病患者118例,按临床诊断分为急性心肌梗塞(AMI)组40例、不稳定性心绞痛(UAP)组36例、稳定性心绞痛(SAP)组42例,对照组40例。测定hs-CRP、同型半胱氨酸(Hcy)的水平,比较各组间的差异。结果 AMI组、UAP组及SAP组的Hcy和hs-CRP水平均比对照组高,差异有显著性(P<0.05);AMI组、UAP组和SAP组Hcy和hs-CRP水平相比,差异有显著性(P<0.05);Hcy和hs-CRP水平变化呈正相关。结论血清Hcy和hs-CRP可能是冠状动脉粥样硬化的标志,参与了冠心病的发病过程,其数值与冠状动脉病变程度密切相关。
Objective To study the correlation between plasma homocysteine （Hcy）. hypersensitive C- reactive protein（ hs- CRP） and coronary heart disease （CHD） ,Methods 118 CHD patients were divided into 3 groups, including 40 eases of acute myocardial infarction （AMI） , 36 eases of unstable angina （UAP） , 42 cases of stable angina （SAP） and control group consisted of 40 healthy people The level of hs - CRP and Hcy was measuredo Person correlation analysis was used to analyze the relationship between the level of hs - CRP and Hcy. Results The levels of KS - CRP and Hcy were significantly higher in AMI, UAP and SAP groups than those in control group （ P 〈 0 . 05 ） o Compared with SAP group, the levels of KS - CRP and Hcy were increased in AMI and UAP groupso The level of KS - CRP was positively associated with the level of Hcy. Conclusions KS - CRP and Hcy may be the markers of coronary atherosclerosis and involved in the process of CHD. The levels of serum Ks- CRP and Hcy are correlate with the severity of CHD.
出处
《菏泽医学专科学校学报》
2010年第2期18-20,共3页
Journal of Heze Medical College
关键词
同型半胱氨酸
超敏C反应蛋白
冠心病
Homocysteine
hypemensitive C- reactive protein
Coronary heart disease （CHD）
