摘要
目的:建立哈尔明碱的微生物转化模型并鉴定转化产物结构。方法:选用丝状真菌短刺小克银汉霉菌AS 3.153对哈尔明碱进行代谢转化研究。结果:得到两种(H1和H2)代谢产物,经鉴定,H1为哈尔酚,H2为氮羟基哈尔明碱。结论:短刺小克银汉霉菌AS 3.153是对哈尔明碱转化的理想微生物模型。通过建立的方法可收集到一定量的代谢产物,为进一步研究药理学和毒理学奠定基础。
Objective：To establish a microbial transformation model of harmine.Method：The cunninghamella blakleana AS 3.153 was chosen for the research of metabolism transformation of harmine.Results：Two metabolites（H1 and H2）were obtaind by this microbial model.H1 was harmol and H2 was N-hydroxyl-harmine.Conclusion：Cunninghamella blakeleana AS 3.153 is an appropriate microbial model for transformation of harmine.A certain amount of metabolites is collected,which makes it possible for further research.
出处
《汕头大学医学院学报》
2010年第2期81-83,88,共4页
Journal of Shantou University Medical College
基金
广东省自然科学基金研究团队资助项目(<潮汕地区特效中药的研制与开发>)
关键词
微生物转化
小克银汉霉菌
药物代谢
哈尔明碱
microbial transformation
Cunninghamella blakeleana
drug metabolism
harmine
