摘要
目的应用诊断试验评价方法及受试者工作特征曲线(ROC曲线)评价孕酮与β-HCG比值在预测异位妊娠中的价值。方法测定68例异位妊娠、65例先兆流产患者的血清孕酮、48hβ-HCG比值,建立ROC曲线,确定诊断异位妊娠的最佳阈值,并评价这两个指标对异位妊娠诊断的准确性。结果通过ROC曲线确定诊断异位妊娠的临界值:孕酮为18.95μg/L,48hβ-HCG比值为1.90;孕酮的敏感度和特异度较高;ROC曲线下面积,孕酮和48hβ-HCG比值分别为0.993和0.953。结论应用ROC曲线确定孕酮和48hβ-HCG比值的临界值对早期异位妊娠有较好的预测价值,孕酮是较48hβ-HCG更好的预测异位妊娠的指标。
Objective To discuss the value of progesterone and β-human chorionic gonadotropin ratio （β-HCG） by diagnostic test and receiver opertating curves （ROC） in the prediction of early ectopic pregnancy. Methods We chose 68 patients with ectopic pregnancy, 65 patients with threatened abortion. Serum progesterone, β-HCG, the second β-HCG of 48 h later and the β-HCG ratio in each group were measured. ROC was constructed and the cut-off value of progesterone and the β-HCG ratio was studied, and the accuracy of each variable was evaluated. Results＇ Cut-off value of progesterone and β-HCG ratio were 18.95μg/L and 1.90, the area under the ROC of each were 0.993 and 0.953. Progesterone predicted ectopic gregnancy with higher sensitivity and specificity. Conclusion Cut-offvalue of progesterone and the β-HCG ratio by ROC can be benefitial for the predicton of diagnosing early ectopic pregnancy, and serum progesterone is a more reliable indicator than the β-HCG raito in the prediction of early ectopic pregnancy.
出处
《临床医学工程》
2010年第7期51-52,共2页
Clinical Medicine & Engineering
关键词
ROC曲线
孕酮
β-HCG比值
异位妊娠
ROC curve
Progesterone
β-human chorionic gonadotropin ratio
Ectopic pregnancy
