摘要
目的观察缬沙坦对原发性高血压的降压效果及其对肾功能的影响。方法 135例原发性高血压患者为缬沙坦组(n=68)和拉西地平组(n=67),治疗前后和治疗期间定期测量血压,治疗前和治疗3个月末检测血清肌酐(Scr)、内生肌酐清除率(Ccr)、尿α1-微球蛋白(α1-MG)、血和尿β2-微球蛋白(β2-MG)。结果 2组患者治疗后1、2、3个月末收缩压和舒张压与治疗前比较均有显著降低,差别有统计学意义(P<0.01)。治疗后同期2组患者血压比较差别无统计学意义(P>0.05)。治疗3个月末2组总有效率比较差别无统计学意义(P>0.05)。治疗3个月末,缬沙坦组尿α1-MG、血和尿β2-MG与治疗前比较均显著下降(P<0.01),但Scr和Ccr与治疗前比较差别均无统计学意义(P>0.05)。拉西地平组各指标治疗3个月末与治疗前比较差别均无统计学意义(P>0.05)。结论缬沙坦对原发性高血压有显著的降压效果,且对肾功能有保护和改善作用。
Objective To observe the effect of valsartan fot treatment of the patients with primary hypertension,and to observe the influence of valsartan on patients,renal function.Methods One hundred and thirty-five patients with primary hypertension were divided into two groups：the valsartan group and the lacidipine group.The serum creatinine（Scr）,creatinine clearance（Ccr）,α1-microglobulin（α1-MG） and β2-microglobulin（β2MG） were detected at pretherapy and 1,2,3 months after treatment.Results The blood pressure at 1,2,3 months after treatment was lower than that before treatment in two groups（P0.01）.There was no statistical difference between two group at the same time after treatment（P0.05）.In the valsartan group,the levels of α1-MG and β2-MG were lower at the 3 months after treatment than these before treatment（P0.01）,but the levels of Scr and Ccr were invariant（P0.05）.There was no difference in the indexes in the lacidipine group pre-and post-treatment（P0.05）.Conclusion Valsartan can obviously degrade the blood pressure in patients with primary hypertension,and can protect and improve the renal function.
出处
《当代医学》
2010年第18期150-151,共2页
Contemporary Medicine
关键词
原发性高血压
缬沙坦
肾功能
primary hypertension
valsartan
renal function
