摘要
目的探讨前列地尔(凯时)对糖尿病肾病患者肾功能不全早期肾内动脉血流变化的影响及彩色多普勒超声的应用价值。方法以30例正常人为对照组,50例经临床确诊的2型糖尿病肾病肾功能不全早期的患者为凯时治疗组。应用彩色多普勒超声对治疗组患者的肾窦部段动脉(SRA)、叶间动脉(IRA)和肾弓形动脉(ARA)进行检查,观察血流的收缩期最大血流速度(Vsmax)、舒张期最低血流速度(Vdmin)和阻力指数(RI)。结果与对照组比较,治疗组用药前SRA、ARA、IRA的Vsmax、Vdmin明显减少,RI值明显升高(P<0.05);用药后SRA的Vsmax明显增加(P<0.05),SRA、ARA的Vdmin明显增加(P<0.05),RI值明显降低(P<0.05)。结论彩色多普勒超声对判断糖尿病肾病肾功能不全有一定价值,凯时注射液对糖尿病患者肾功能不全早期肾内动脉血流改善有积极的作用,RI可作为评价凯时注射液疗效的敏感指标。
Objective To investigate the effects of Alprostadil on the change of hemodynamic parameters of intrinsic artery of kidney in the early stage of renal inadequacy in diabetic nephropathy and the application value of Color doppler ultrasonography. Methods Thirty normal subjects were in control group, while fifty subjects were in the treatment group who were diagnosed as being in the early stage of renal inadequacy in diabetic nephropathy. Color doppler ultrasonography was used to examine the segmental renal artery （SRA）、interlobular artery （IRA） and arcuate renal cortex artery （ARA）, meanwhile observation and analyses were made towards its peak systolic blood flow velocity （Vsmax） 、end diastolic blood flow velocity （Vdmin） and pulse index （RI）. Results Compared with the control group, Vdmin and Vsmax of SRA, ARA and IRA was reduced markedly before Alprostadil treatment, but RI rised remarkably （P 0.05）. Vsmax of SRA and Vdmin of SRA and ARA went up evidently （P 0.05）, but RI decreased significantly （P 0.05）. Conclusions Color doppler ultrasonography is of value in assessing renal inadequacy of diabetic nephropathy. Alprostadil plays an active role in improving renal bloodstream in the early stage of renal inadequacy in diabetic nephropathy, and RI can be served as a sensitive index to evaluate its effect.
出处
《北京医学》
CAS
2010年第7期522-524,共3页
Beijing Medical Journal
关键词
糖尿病肾病
彩色多普勒超声
凯时注射液
肾内动脉
阻力指数
Diabetic nephropathy
Color doppler ultrasonography
Alprostadil
Intrinsic artery of kidney
Resistance index
