摘要
目的:对中药与抗菌药物随机对照治疗尿路感染的有效性进行系统评价。方法:按照系统评价的要求全面检索中国学术期刊全文数据库、万方数据库,对符合纳入标准的18篇文献进行Meta分析。结果:与对照组相比,治疗组及各亚组包括单纯使用中药组、中药联合抗菌药物组、老年性及慢性尿路感染组的有效率比数比的合并值分别为3.99、3.95、3.95、4.23、4.35,95%CI分别为(2.97,5.37)、(2.80,5.80)、(2.80,5.80)、(2.61,6.83)、(2.64,7.18);复发率比数比的合并值为0.25,95%CI为(0.17,0.37);所有研究均显示P<0.00001。结论:Meta分析结果显示,中药治疗尿路感染比单纯使用抗菌药物的临床有效率更高,复发率更低。但由于纳入研究可能存在选择性偏倚、实施偏倚以及发表偏倚,影响结果的可靠性,故建议实施多中心、大样本的临床随机对照试验。
OBJECTIVE：To evaluate the effectiveness of TCM and antibiotics in the treatment of urinary tract infection（UTI） systematically.METHODS：According to the requirements of Cochrane systematic review,literatures were retrieved from CNKI and Wanfang database.A meta-analysis was performed on 18 literatures conforming to inclusion criteria.RESULTS：Compared with control group,the OR value of treatment group and subgroups including TCM group,TCM combined with antibiotics group,chronic UTI group and senile UTI group were 3.99,3.95,3.95,4.23,4.35,respectively.The 95%CI of those groups were（2.97,5.37）,（2.80,5.80）,（2.80,5.80）,（2.61,6.83）,（2.64,7.18）.The OR value was of treatment group 0.25（95%CI：0.17,0.37;P〈0.000 01）.CONCLUSION：Results of meta-analysis shows that TCM is superior to antibiotics in the treatment of UTI with low recurrence rate.Lager scale multicenter randomized controlled trials are required due to the potential risk of selection bias,performance bias and publication bias.
出处
《中国药房》
CAS
CSCD
北大核心
2010年第27期2569-2572,共4页
China Pharmacy
关键词
中药
抗菌药物
尿路感染
系统评价
TCM
Antibiotics
Urinary tract infection
Systematic evaluation
