摘要
目的探讨广东地区Ａｌｚｈｅｉｍｅｒ病（ＡＤ）患者与ａｐｏＥε４之间的关联性及性别的影响。方法应用聚合酶链反应－限制性片段长度多态性分析（ＰＣＲ－ＲＦＬＰ）技术对４４例晚发性散发性ＡＤ患者、３７例非痴呆老年人的ａｐｏＥ基因进行分型。结果ａｐｏＥε４与晚发性ＡＤ有显著的关联；携带１个或１个以上ε４者与无ε４携带者比较，相对危险度（ＯＲ值）为４．０８，且随ε４基因剂量增加，不含、含１个和含２个ａｐｏＥε４ＡＤ的患病率（分别为４０．０％、６７．０％和１００％）上升，发病年龄明显提前，分别为（８０．５±１．７）、（７９．５±１．６）和（７１．７±１．８）岁（Ｐ＜０．０１）；ＡＤ患者不同性别之间ａｐｏＥε４基因型频率和等位基因频率差异无显著性（Ｐ＞０．０５）。结论ａｐｏＥε４是晚发性ＡＤ发病的危险因素；ＡＤ患者的性别因素与ａｐｏＥε４无相关性。
Objective To discuss the association of Alzheimer's disease (AD) in Guangdong with apoEε4 and its influence by sex. Methods The polymerase chain reaction restriction fragment length polymorphism (PCR RFLP) technique was used to analyze the apoE allele genotype of 44 late onset AD patients and 37 non dementia elderly controls. Results There was a significant association of apoE4 allele gene with late onset AD. To compare the carrier of one or more ε4 with none ε4, OR (odds ratios) value was 4 08. Furthermore, with the increase of ε4 gene dose, the incidence of AD was increased and the age of onset was earlier ( P <0 01). There was no significant difference of the frequency of apoEε4 allele gene and genotype between women and men in AD patients ( P >0 05). Conclusions This study indicates that apoEε4 allele gene is risk factor for late onset AD and supports the view that there is no significant association of apoEε4 with sex in AD patients.
出处
《中华老年医学杂志》
CAS
CSCD
北大核心
1999年第1期10-12,共3页
Chinese Journal of Geriatrics
基金
国家自然科学基金
