摘要
目的:探讨钙调神经磷酸酶基因多态性与有氧耐力表型初始值及耐力训练效果的关联性。方法:102名无训练史的青年健康男子完成18周有氧耐力训练,测试训练前后的VO2max和12km/h下的跑节省化(VO2)。采用PCR-RFLP和MALDI-TOFMS对钙调神经磷酸酶5个编码基因的55个单核苷酸多态性进行分型。结果:(1)VO2max初始值与单核苷酸多态性rs2850965和rs3804423关联;(2)VO2max训练敏感性与单核苷酸多态性rs3804358和rs4671887关联;(3)跑节省化的训练敏感性与单核苷酸多态性rs3739723关联。结论:钙调神经磷酸酶基因多态性可能部分解释有氧运动能力的个体差异性。
Objective The association of polymorphisms in calcineurin genes with the phenotype of aerobic endurance, as well as the effect of training on the calcineurin gene isoforms were investigated. Methods One hundred and two healthy young men of Han nationality in northern China were enrolled in this study. The possible association of 55 polymorphisms in the calcineurin gene isoforms PPP3CA,PPP3CB,PPP3CC,PPP3R1 and PPP3R2 with the maximal oxygen uptake（VO2max） and running economy（RE） at baseline levels, as well as the response of VO2max and RE to the 18-week endurance training program was studied. Two-way （genotype, training） ANOVA was used to compare the baseline VO2max and RE among genotype polymorphisms with the VO2 max and RE after training. Results We found a significant association between： （1）baseline VO2max and the rs2850965 and rs3804423 polymorphism in the PPP3CA gene ; （2）training responsiveness of VO2max and both the rs3804358 polymorphism （PPP3CA） and the rs4671887 polymorphism （PPP3Rt）; （3）training responsiveness of RE and PPP3R2. Conclusion Results suggest that polymorphisms in the calcineurin genes possibly could partially explain the individual variations in aerobic endurance. Further study of this association is needed.
出处
《中国运动医学杂志》
CAS
CSCD
北大核心
2010年第4期407-413,共7页
Chinese Journal of Sports Medicine
基金
国家体育总局体育科学研究所基本业务费(06-15)
国家科技部科技支撑计划(2003BA904B04)
