摘要
目的探讨富于巨细胞的孤立性纤维性肿瘤(GR-SFT)的临床病理特征和鉴别诊断。方法用常规病理学检查和免疫组化方法 ,观察2例富于巨细胞的孤立性纤维性肿瘤的临床特点、病理学特征、免疫表型和鉴别诊断,并结合文献复习进行总结。结果肿瘤界限清楚,在孤立性纤维肿瘤组织学改变的基础上,具有灶性或广泛分布的多核巨细胞;多核巨细胞的形态和分布具有特征性,多分布于单核间质细胞稀疏、胶原化明显的区域。多核巨细胞和单核间质细胞CD34、CD99和bcl-2阳性。结论 GR-SFT是孤立性纤维性肿瘤的一种特殊类型,主要发生于40岁的成人,女性略多见。多核巨细胞的形态、分布和免疫表型具有诊断意义。需与巨细胞血管纤维瘤、巨细胞纤维母细胞瘤、纤维组织细胞瘤、丛状纤维组织细胞瘤、软组织巨细胞瘤、恶性纤维组织细胞瘤(多形性未分化肉瘤)等良、恶性肿瘤相鉴别。巨细胞分化是瘤组织的一种退行性改变。
Objective To investigate the clinicopathologic features and differential diagnosis of giant cell-rich variant of solitary fibrous tumors. Methods Routine pathological examinations, immunohistochemical staining of 2 cases of GRSFT and literature review were performed. The clinical features, pathological changes, immunophenotypes and differential diagnosis of the tumor were summaried in this study. Results Grossly, the tumor mass was well circumscribed. Histologically, there were muftinucleated giant cells distributed focally or diffusely on the background of histological changes of solitary fibrous tumors. The shape and distribution of giant cells were characteristic. Giant cells were mainly located in areas with dense collagen deposition and sparseness of mononuclear mesenchymal cells. Tumor cells, including giant cells, expressed CD34, CD99 and Bcl-2. Conclusion Giant cell-rich solitary fibrous tumor is a special variant of solitary fibrous tumors. Patients are mainly adults aged above 40 years, and with a female predominance. The shape, distribution and immunophenotype of giant cells are significant in the pathological diagnosis. The tumor should be distinguished from other benign and malignant soft tissue tumors including giant cell angiofibroma, giant cell fibroblastoma, fibrous histioeytoma, plexiform fibrohistioeytie tumor, giant cell tumor of soft tissue and malignant fibrous hisiocytoma/ undifferentiated sarcoma. The appearance of giant cells probably represents a degenerative phenomenon.
出处
《诊断病理学杂志》
CSCD
2010年第3期194-197,共4页
Chinese Journal of Diagnostic Pathology
关键词
孤立性纤维性肿瘤
巨细胞
病理学
鉴别诊断
Solitary fibrous tumor
Giant cell
Pathology＇
Differential diagnosis
