摘要
内脂素是一种主要由内脏脂肪细胞分泌的蛋白质细胞因子,具有调节糖脂代谢、炎症等多种生物学活性。临床研究发现肥胖、2型糖尿病和代谢综合征患者血清中内脂素显著增高,其中伴动脉粥样硬化患者更为显著,从而推测血清中内脂素可能与糖尿病大血管并发症的发生密切相关。文章拟对内脂素的生物学效应及在糖尿病大血管并发症发生发展中的作用进行综述。
Visfatin is a novel pro-inflammatory adipokine which was predominantly produced and secreted in visceral fat,involved in regulating glucose and lipid metabolism,inflammation,and so on.In clinical study,serum visfatin was obviously elevated in patients with obesity,type 2 diabetes and metabolic syndrome,especially higher among patients with atherosclerosis.The results suggest that visfatin is closely correlated to macrovascular complications in diabetes mellitus.This paper will review the biological effects of visfatin and its influence on macrovascular complications in diabetes mellitus.
出处
《中国动脉硬化杂志》
CAS
CSCD
北大核心
2010年第5期412-414,共3页
Chinese Journal of Arteriosclerosis
基金
国家自然科学基金(30771038
30570744)
关键词
内脂素
炎症因子
糖尿病
血管并发症
Visfatin
Inflammatory Cytokines
Diabetes Mellitus
Vascular Complications
