摘要
目的:研究博落回(Macleaya Cordata(Willd)R.Br)提取物对皮癣致病真菌的抑制作用。方法:以常见的皮癣真菌包括红色毛癣菌(Trichophyton rubrum),许兰黄癣菌(Trichophyton schoenleini),玫瑰色癣菌(Trichophyton rosaceum),须癣毛癣菌(Trichophyton mentagrophytes),絮状表皮癣菌(Epidermophyton floccos)为供试病原菌,通过采用琼脂打孔法;平板稀释法;固体培养基稀释法;对博落回提取物进行离体抑菌活性以及最低抑菌浓度的测定。结果:博落回提取物有抑制皮癣真菌的活性,博落回提取物对红色毛癣菌,许兰黄癣菌以及絮状表皮癣菌的最低抑菌浓度均为1.6mg/mL,对玫瑰色癣菌,须癣毛癣菌的最低抑菌浓度为0.8mg/mL。结论:博落回提取物对上述几种皮癣病原真菌有明显的抑制作用,随着浓度的增大,其抑制作用明显增加。
AIM：To research inhibitory effects of plumepoppy （Macleaya cordata） extract on dermophytosis. METHODS：A series of experimental methods,including agar hole method,plate dilution method and solid medium dilution method were initiated into pathogenic organism of skin disease,including Trichophyton rubrum（Tru）,Trichophyton schoenleini（Ts）,Trichophyton rosaceum（Tro）,Trichophyton mentagrophytes（Tm）,and Epidermophyton floccosum（Ep） to determinate in vitro antibacterial Minimum inhibitory concentration（MIC） by plumepoppy extract that macerated with acidic water （pH = 3）. RESULTS：Macleaya cordata alkaloids had significant effect on these five kinds of skin fungi. The MIC of Tru,Ts,Ep was 1. 6 mg/mL; The MIC of Tro and Tm was 0. 8 mg/ mL. CONCLUSION：The plumepoppy extract has anti-fungus activaties,with the increasing concentration,the inhibition effect rapidly goes up.
出处
《中成药》
CAS
CSCD
北大核心
2010年第7期1108-1111,共4页
Chinese Traditional Patent Medicine
基金
贵州大学研究生创新基金省级资助项目(2009006)
关键词
博落回生物碱
皮癣真菌
抑制活性
Macleaya alkaloids
skin fungus
anti-fungus activaties
