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肝肾综合征的发病机制及早期诊断研究进展 被引量:7

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摘要 肝肾综合征(hepatorenalsyndrome.HRS)是肝硬化或其他严重肝病时发生的一种预后极差的严重并发症.以肾功能衰竭、血流动力学改变和内源性血管活性系统激活.肾动脉显著收缩导致肾小球滤过率降低为特征,临床以少尿或无尿及血尿素氮、肌酐升高等为主要表现,但肾脏无器质性病变。在肝功能衰竭患者中.HRS发生率为60%~80%。一旦发生HRS,治疗相当困难,预后差,3个月病死率高达80%~100%。迄今为止,HRS的金标准治疗为肝移植。用血管升压素拮抗剂做维持治疗。
出处 《实用医学杂志》 CAS 北大核心 2010年第13期2267-2269,共3页 The Journal of Practical Medicine
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