摘要
目的:观察疏血通和氟伐他汀对糖尿病肾病(DN)患者的保护作用。方法:52例糖尿病肾病患者,均为临床肾病期,随机分为两组,治疗组、对照组各26例,两组患者均予以糖尿病饮食、控制血糖和降血压等常规治疗。对照组疏血通注射液6ml/d静滴,1疗程为3周;治疗组在对照组的基础上加用氟伐他汀40mg每晚1次口服,治疗2月。于治疗前后分别检测血清肌酐(Scr)、24小时尿蛋白(24hUP)、低密度脂蛋白(LDL-C)、血浆脂蛋白-a[LP(a)]、C反应蛋白(CRP)等指标,并进行比较。结果:治疗后和治疗前比较,对照组24hUP、Scr明显降低(P<0.05),治疗组24hUP、Scr、LDL-C、LP(a)、CRP下降(P<0.01或0.05);治疗后3w及2months后,治疗组24hUP、Scr、LDL-C、LP(a)、CRP较对照组下降(P<0.05)。结论:疏血通联合氟伐他汀治疗糖尿病肾病减轻尿蛋白、延缓肾功能减退方面更加安全有效。
Objective：To investigate the protective effects of Shuxuetong and fluvastatin on patients with diabetic nephropathy（DN）.Methods：A total of 52 cases of patients with DN were randomly divided into two groups：Treated group（n=26） and Control group（n=26）.All patients were treated with diabetic diet,controlling blood glucose and blood pressure.Patients in control group were also treated with Shuxuetong injection（6ml/d,for three weeks）,while patients in treated group were treated with Shuxuetong and fluvastatin（40mg/d,for 2 months）.Indexes such as Scr,24hUP,LDL-C,LP（a）,CRP were measured and compared between groups before treatment and two months after treatment.Results：In Control groups,24hUP and Scr were lower than those before treatment（P0.05）,while in Treated groups 24hUP,Sc,LDL-C,LP（a） and CRP all were lower than those before treatmen（tP0.01 or P0.05）.Three weeks or Two months after treatment,24hUP,Scr,LDL-C,LP（a） and CRP were significantly lower in Treated group than Control group（P0.05）.Conclusion：Shuxuetong and fluvastatin had protective effects on patients with DN by reducing UP and preventing renal dysfunction.
出处
《现代生物医学进展》
CAS
2010年第12期2319-2321,共3页
Progress in Modern Biomedicine
关键词
疏血通
氟伐他汀
糖尿病肾病
Shuxuetong
Fluvastatin
Diabetic nephropathy
