摘要
目的研究盐酸布比卡因的电化学行为,建立盐酸布比卡因电化学检测方法。方法采用循环伏安(CV)进行盐酸布比卡的电化学性质的研究,差分脉冲(DPV)法进行盐酸布比卡因的含量检测。结果在0.01mol/L高氯酸四丁基铵缓冲溶液(TBAP)中,盐酸布比卡因的微量水溶液在铂电极上的氧化峰电流与其浓度在1×10-5～2×10-4mol/L的范围内呈良好的线性关系,线性回归相关系数为0.9958,检出限为1.0×10-5mol/L。结论该方法准确可靠,操作简便、快速,重现性好,可应用于盐酸布比卡因原料药的检测。
Objective To study the electrochemical behavior of bupivacaine hydrochloride and to establish an electrochemical method for determination of bupivacaine hydrochloride.Methods The electrochemical behavior of bupivacaine hydrochloride was studied by cyclic voltammetry（CV）,and differential pulse voltammetry（DPV）was used to determine the contents of bupivacaine hydrochloride.Results In a 0.01 mol/L tetrabutylammonium perchlorate（TBAP）buffer solution,the oxidization peak current on the platinum electrode in the bupivacaine hydrochloride solution was in a good linear relation over a concentration range of 1.0×10-5-2.0×10-4 mol/L,with the r value being 0.995 8,and a detection limit of 1×10-5 mol/L（by DPV）.Conclusion Our method is accurate,easy to perform,and with good repeatability,and it can be used to determine bupivacaine hydrochloride content in bupivacaine hydrochloride raw medicine.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
2010年第7期794-795,共2页
Academic Journal of Second Military Medical University
基金
安徽省教育厅自然科学基金(2006KJ151B
2006KJ022C)
安徽省教育厅青年教师科研资助计划(2005jq1167)~~
关键词
布比卡因
电化学
bupivacaine
electrochemistry analysis
