摘要
目的利用Meta分析评价醒脑静注射液治疗脑梗塞的临床疗效。方法计算机检索中国生物医学文献数据库(1981～2010)及其他数据库中的醒脑静注射液治疗脑梗塞的随机对照研究,并进行方法学质量评价,采用RevMan 4.2软件进行Meta分析。结果共纳入34篇随机对照研究(共3233例患者)。与基础治疗组相比,醒脑静注射液可明显提高脑梗塞患者的治疗总有效率[RR=3.85,95%CI(2.97～5.00),P<0.000 01]。其中有4篇文章比较了显效率,2组间显效率差异具有统计学意义[RR=3.93,95%CI(2.63～5.87),P<0.000 01]。治疗组神经功能缺损评分的改善明显优于对照组[SMD=-0.71,95%CI(-1.20～-0.21),P=0.005]。结论目前的有限证据表明,醒脑静注射液相对对照组可以部分提高脑梗塞患者的总有效率,改善神经功能缺损,但由于目前的临床研究质量较低,尚需大量严格设计的、多中心的随机对照试验加以证实。
Objective To evaluate the clinical efficacy of Xingnaojing injection for treating patients with cerebral infraction using Meta-analysis.Methods Chinese Biomedical Documentary Database（1981～2010） were searched,and randomized controlled trials（RCTs） on Xingnaojing injection were collected.Meta-analysis of the included trials was carried out to evaluate the efficacy of Xingnaojing injection.Results Thirty four RCTs involving 3233 patients with cerebral infraction were included.Xingnaojing was more effective in increasing total effective rate and effectual rate compared with basic treatment[RR=3.85,95%CI（2.97～5.00）,P〈0.000 01;RR=3.93,95%CI（2.63～5.87）,P〈0.000 01].In improving neurologic impairment,Xingnaojing was also more effective than basic treatment[SMD=-0.71,95%CI（-1.20～-0.21）,P=0.005].Conclusion The limited evidences showed that Xingnaojing may be superior to basic treatment in improving total effective rate,effectual rate and neurologic impairment.Large-scale and well-designed clinical trials are needed to give more persuasive evidences to prove the efficacy of Xingnaojing injection due to some low-quality trials.
出处
《今日药学》
CAS
2010年第7期44-51,共8页
Pharmacy Today
关键词
醒脑静注射液
脑梗塞
META分析
Xingnaojing injection
cerebral infraction
Meta-analysis
