摘要
目的研究我国儿童１型糖尿病的发病率。方法中国预防医学科学院ＷＨＯＤｉａＭｏｎｄ项目中国协调中心在全国建立了登记网络。１６个省、市和自治区的２０个地区根据该中心的计划和要求，对１９８８～１９９６年期间诊断的＜１５岁的１型糖尿病病例进行了回顾性的登记。该研究覆盖＜１５岁儿童１９００余万，登记到我国九个民族，共发现８８３例１型糖尿病病人。结果显示该时期总的确定校正发病率为０．５９／１０万人年〔９５％可信区间（ＣＩ）：０．５７～０．６０〕，其中男０．５２／１０万人年（９５％ＣＩ：０．５０～０．５４），女０．６６／１０万人年（９５％ＣＩ：０．６４～０．６８）。按１９９０年全国人口构成比例标化的确定校正发病率为０．５７／１０万人年。结论我国儿童１型糖尿病的发病率在逐年上升；发病率随年龄的增长而增加；民族间的发病率差异达１２倍；发病率在不同地区之间呈现明显的南低北高现象。
Objective To investigate into the incidence rate (IR) of childhood type 1 diabetes mellitus in China. Methods A nationwide register networkwas establishedby theWHODiaMondProject China Coordinating Center,ChineseAcademyofPreventive Medicine (CAPM). Coordinated by that center and following the standardized protocol, 20 local centers in 16 provinces, autonomous regions and municipalities of China registered retrospectively the newly diagnosed cases of type 1 diabetes mellitus with onset age<15 years between 1988～1996. Results The population under investigation was more than 19 million, and 883 type 1 diabetes mellitus from 9 nationalities were registered. The overall ascertained and corrected type 1 diabetes IR was 0.59 per 100000 person year. ThegenderspecificIRswere0.52/100000 (95% CI: 0.50～0.54) for males and 0.66/100000 (95% CI:0.64～0.68) for females. The standard ascertained and corrected IR according to the national age specific population in 1990 was 0.57 per 100000 person year, which was the lowest rate ever reported by other countries. Conclusions The IRs of childhood type 1 diabetes mellitus in China were increasing with passage of time; the age specific IRs increased with age; the various ethnic groups had over a 12 fold difference in IR; and the overall IR was significantly higherin north China than in south regions.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
1999年第1期3-7,共5页
Chinese Journal of Endocrinology and Metabolism
基金
国家自然科学基金
美国NIH部分资助
关键词
糖尿病
Ⅰ型
流行病学
发病率
儿童
Diabetes mellitus, type 1 Epidemiology Incidence
