3[1]Kemppainer M, Raiha I, Sourander LA. marked increase in the incidence of colorectal cancer over two decades in Southwest Finland [ J ]. J Clin Epidemiol, 1997,50(2): 147
4[2]Bos JL, Fearon ER, Hamilton SR, et al. Provalance of ras gene mutaions in human colorectal cancer. Nature, 1987,327: 293
5[3]Ogelstein B, Fearon ER, Hamilton SR, et al. Genetic alterations during colorectal - tumor development. N Engl J Med, 1988,319:527
6[7]Masahide, Ikeguchi. Computerized nuclear morphometry is a useful technique for evaluating the high metastic potiential of colorectal adenocarcinoma [J]. Cancer, 1999,86:1944
7[2]Leslie NR,Downess CP.PTEN function:how normal cells control it and tumour cells lose it[J].Biochem J,2004,382:1-11.
8[3]Hvoeijmarkers J H.Genome maintenance mechanisms for preventing cancer[J] Nature,2001,411(6835):366-374.
9[4]Mutter GL,Lin MC,Fitzgerald JT,et al.Altered PTEN expression as a diagnostic marker for the earliest endometrial precancers[J].J Natl Cancer Inst,2000,92(11):924-930.
10[6]Ito K,Sasano H,Yoshida Y,et al.Immunohistochemical study of Cyclin D and E and Cyclin dependent kinase(CDK)2 and 4 in human endometrial carcinoma[J].Anticancer Res,1998,18 (3A):1661 -1664.
