摘要
目的：为阐明淫羊藿苷在体内的作用形式，对淫羊藿苷的代谢产物及活性进行研究。方法：将淫羊藿苷给大鼠ｉｇ后，分析、分离并鉴定了其在小肠、尿、胆汁中的主要代谢产物。结果：在小肠及尿中鉴定有淫羊藿次苷Ｉ（ｉｃａｒｉｓｉｄｅＩＩ）及淫羊藿素（ｉｃａｒｉｔｉｎ），胆汁中有淫羊藿素３ＯαＬ鼠李吡喃糖基７ＯβＤ葡萄吡喃糖醛酸苷（ｉｃａｒｉｔｉｎ３ＯαＬｒｈａｍｎｏｐｙｒａｎｏｓｙｌ７ＯβＤｇｌｕｃｏｐｙｒａｎｕｒｏｎｏｓｉｄｅ）和淫羊藿次苷ＩＩ，并对淫羊藿苷在大鼠体内主要代谢途径进行了探讨。结论：淫羊藿苷在吸收之前已发生代谢，在体内主要是以其代谢产物的形式存在。
AIM: To evaluate the pharmacological action
of icariin in traditional Chinese medicines. METHODS: Icariin was given orally to rats, the major
metabolites of icariin in gastric, small intestinal, urine and bile samples were determined and
isolated by HPLC and identified by chemical and spectroscopic evidences. RESULTS: Two
metabolites, icariside II and icaritin in both small intestine and urine, and two metabolites,
icaritin 3 O α L rhamnopyranosyl 7 O β D glucopyranuronoside and icariside
II in bile were identified. The major metabolic route of orally administered icariin in rats was
also proposed. CONCLUSION: Icariin is metabolized prior to absorption and exists mainly as its
metabolites in vivo .
出处
《药学学报》
CAS
CSCD
北大核心
1999年第3期222-226,共5页
Acta Pharmaceutica Sinica
基金
辽宁省科学技术基金
关键词
淫羊藿苷
大鼠
中药
代谢产物
icariin
icariside II
icaritin
icaritin 3 O α L
rhammopyranosyl 7 O β D glucopyranuronoside
metabolite
