摘要
目的:对软紫草与硬紫草中萘醌类化学成分进行研究。方法:利用硅胶柱色谱、葡聚糖凝胶柱色谱等方法分离纯化,通过理化常数和波谱数据鉴定化合物结构,利用圆二色谱测定萘醌化合物绝对构型。结果:从软紫草中分离得到6个化合物,鉴定为阿卡宁(AE-1),乙酰阿卡宁(AE-2),β,β-二甲基丙烯酰阿卡宁(AE-3),异丁酰阿卡宁(AE-4),α-甲基-正丁酰阿卡宁+异戊酰阿卡宁(AE-5),β-乙酰氧基异戊酰阿卡宁(AE-6);从硬紫草中分离鉴定了6个化合物,分别为紫草素(LE-1),乙酰紫草素(LE-2),β,β-二甲基丙烯酰紫草素(LE-3),异丁酰紫草素(LE-4),α-甲基-正丁酰紫草素+异戊酰紫草素(LE-5),β-羟基异戊酰紫草素(LE-6)。结论:软紫草中萘醌类化学成分绝对构型为S型,硬紫草中为R型。
Objective： To investigate naphthaquinones in Arnebia euchroma （Royle） Johnst. and Lithosperrnum erythrorhizon Sieb. et Zuec. . Methods： Compounds were isolated by column chromatography and structures were elucidated through physicochemical and spectral analyses, absolute configuration of naphthaquinone was determined by circular dichroism spectra. Results： Six compounds were obtained from the root of Arnebia euchroma （Royle） Johnst. and identified as alkannin, acetylalkannin, β,β-dimethylacrylalkannin, isobutyalkannin, isovalerylalkannin ＋ α-methyl-n-butylalkannin and β-acetoxyisoralerylalkannin; Six compounds were obtained from the root of Lithos-permum erythrorhizon Sieb. et Zucc. and identified as shikonin, acetylshikonin, β,β-dimethylacrylshikonin, isobutylshikonin, isovalerylshikonin ＋ α-methyl-nbutylshikonin, β-hydroxyisoralerylshikonin. Conclusion： Absolute configuration of naphthaquinones from Arnebia euchroma （Royle） Johnst. was S and those from Lithos-permum erythrorhizon Sieb. et Zucc. was R.
出处
《中国现代中药》
CAS
2010年第7期15-18,共4页
Modern Chinese Medicine
基金
新疆石河子大学高层次人才科研启动资金专项(RCZX200664)
关键词
软紫草
硬紫草
萘醌
绝对构型
Arnebia euchroma （Royle） Johnst.
Lithos-permum erythrorhizon Sieb. et Zucc.
Naphthaquinones
Absolute configuration
