摘要
许多大规模临床试验已证实他汀类药物明显降低冠状动脉性心脏病的发病率和心血管事件的发生,强化调脂治疗在极高危患者中的地位日益受到重视。与其他他汀类药物相比,瑞舒伐他汀具有一些有利的药理特性,一系列临床研究也显示,此药对各类血脂异常患者的低密度脂蛋白胆固醇降低效果均显著优于同类其他药物,而且还有改善血管内皮功能和稳定斑块、抗氧化、抗炎等非调脂作用。现综述瑞舒伐他汀目前的研究进展。
Many recent clinical trials have reinforced the benefits of using statins,especially in instances where there is an emphasis on achieving low LDL cholesterol levels for the optimal management of high risk patients.Some of the cholesterol-independent effects of statins may be mediated through enhancing the stability of atherosclerotic plaques.When compared with other statins,rosuvastatin has had significant beneficial pharmacological effects including improving blood vessel function,reversing plaque build-up,and anti-inflammation.Additionally a series of clinical studies have indicated it may have even more advantages.This article summarizes research that has been done into rosuvastatin and its effects up to the present.
出处
《心血管病学进展》
CAS
2010年第4期585-588,共4页
Advances in Cardiovascular Diseases
关键词
瑞舒伐他汀
研究进展
rosuvastatin
research progress
