摘要
目的评价柴芍承气汤治疗急性重症胰腺炎(SAP)的有效性和安全性。方法计算机检索和手工检索收集有关柴芍承气汤治疗SAP的随机对照试验和(或)半随机对照试验,采用Handbook4.2.2推荐的方法 评价纳入研究的质量,对符合纳入标准的研究采用RevMan4.2.7进行Meta分析。最终纳入9篇中文文献534例患者。结果基础治疗加柴芍承气汤组在病死率、并发症发生率、总有效率、住院时间等方面均优于基础治疗组,且未发生严重不良反应。结论现有临床证据表明,基础治疗加柴芍承气汤治疗SAP疗效优于单纯基础治疗,但鉴于纳入研究文献质量较低,使论证强度受到一定限制,有必要进一步开展多中心、大样本随机临床对照试验评价其疗效和安全性。
Objective To assess the effectiveness and safety of chaishao chengqi decoction in the treatment of patients with severe acute pancreatitis. Methods We searched studies about chaishao chengqi decoction in the treatment of patients with severe acute pancreatitis . Randomized controlled trials or quasi-randomized trial of chaishao chengqi decoction for acute pancreatitis, we evaluated the quality of the included studies by Handbook 4.2.2 recommend standard and analyzed data by Cochrane Collaboration＇s RevMan 4.2.7. We included 9 trials （n= 534）. Results Meta-analyses showed that the clinical effective rate of ehaishao chengqi decoction plus based treatment group significantly was higher than based treatment group. Conclusion The current evidence showed chaishao chengqi decoction plus based treatment has better effectiveness when compared with based treatment. Further high quality and large sample randomized controlled trials should be carried out.
出处
《重庆医学》
CAS
CSCD
北大核心
2010年第15期1993-1994,1997,共3页
Chongqing medicine
关键词
柴芍承气汤
急性重症胰腺炎
系统评价
chaishao chengqi decoction
severe acute pancreatitis
systematic review
