摘要
骨巨细胞瘤是有较强局部侵袭性的骨肿瘤，常规手术局部复发与否，仅依组织学改变难以预测，本研究检测ＧＣＴ增殖指数，凋亡率及ＰＩ／ＡＲ比值，研究其对预后的判断价值。
Objective: Giant cell tumor of bone (GCT) is a locally aggressive tumor whose clinical behavior is difficult to predict hased on its microscopic. appearance alone. The proliferation index (PI) 、apoptotic rate (AR) and PI/AR in GCT were studied to assess their value as prognostics parameters. Method: Streptavidin － Biotin － peroxidase Compex (SABC )methods, monoclonal antibody against PCNA and terminal deoxynucleotidyl transferase (TDT) methods of staining apoptotic cells were employed on 34 formalin fixed paraffin embeded tissue from 20 nonrecurrent (NR－GCT)and 14 recurrent (R－GCT)giant cell tumor of bone. All patients were treated by curretage, cautery with 50% aqueous solution of zinc chloride and bone grafting and were foillowed up by 5－17 years. mean follow up were 10. 7 years. Results: Mean values ± standard devition ( ± s) for PI were 9. 41 ± 2. 35 (% ) (NH－GCT); 10. 21 ± 3. 52 (% ) (R－GCT), P > 0 . 05; ± s for AR were 3. 65 ±1. 86 (% ) (NH－ACT). 2. 37 ±0. 93 (% ) (R－GCT), P < 0. 05; ± s for PI/AR were 2. 62 ± 1. 52 (NR－GCT), 4. 38 ±2. 03 (R－ACT) P < 0. 01. Conclusion: CCTs of lower AR, or higher PI/AR treated by curretage, cautery with 50% zine chloride and bone grafting were more possibly recurrent than those of higher AR, or lower PI/AR after operation. AR and PI/AR may be helpful progllostic parameters to predict the recurrence of CCTs.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
1999年第2期146-148,共3页
Chinese Journal of Cancer
关键词
骨肿瘤
骨巨细胞瘤
预后
细胞凋亡
PCNA
Giant cell tumor of bone: Immunohistochemistry
Apoptosis
PCNA
Prognosis
