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复方甘草锌与氨来呫诺口腔复合膜的处方筛选 被引量:8

Formulation optimization of compound licorzinc and Amlexanox oral complex pellicle
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摘要 目的采用均匀设计法及相关分析对复方甘草锌与氨来呫诺口腔复合膜的处方进行优选,方法不同配比的聚乙烯醇(PVA)、羟丙甲基纤维素(HPMC)、丙二醇为成膜材料,以膜剂的柔软性、均匀性、光滑性、透明性作为考察指标,采用均匀设计法及相关分析筛选最优处方并进行透皮吸收试验。结果最佳成膜材料处方为:PVA6.5g,HPMC0.1g,丙二醇6.0g。透皮实验结果表明,甘草锌和氨来呫诺都滞留在皮内,可以更好地促进溃疡面愈合。结论采用上述配比的处方可制备出优良的口腔溃疡复合膜,满足缓释、安全的要求。 Objective To optimize the prescription of compound licorzinc and Amlexanox oral complex pellicle and improve the quality control by using uniform design and correlation analysis. Methods Different ratio of PVA, HPMC and propylene glycol were used as the composite materials of the pellicle. Softness, uniformity, smoothness, and transparency of the pellicle were regarded as parameters. Uniform design and correlation analysis were adopted for the formulation optimization. Cutaneous absorption test was carried out. Results The optimal formulation of film-forming materials was PVA: 6.5 g, HPMC. 0. 1 g, propylene glycol: 6.0 g. The experimental results showed that licorzinc and Amlexanox remained in skin and promoted ulcer healing. Conclusion Preparation of the above prescription can be excellent oral complex pellicle to meet the requirements of slow release and safety.
出处 《现代药物与临床》 CAS 2010年第3期207-210,共4页 Drugs & Clinic
关键词 口腔复合膜 甘草锌 氨来咕诺 均匀设计 相关分析 透皮实验 complex peliicle licorzinc Amlexanox uniform design correlation analysis transdermal test
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参考文献7

  • 1种清云.中医药治疗口腔溃疡之我见.陕西中医函授,2001,1(1):18-18.
  • 2刘亚梅,季金坤,刘青.甘草锌治疗复发性口疮36例疗效观察[J].齐鲁药事,2005,24(2):118-119. 被引量:2
  • 3卞志家,刘衡,王春龙,龚莉.氨来呫诺经对兔口腔颊黏膜的渗透性[J].中国药学杂志,2006,41(9):683-685. 被引量:4
  • 4Khandwala A, Richard G. Van Inwegen, et al. 5% Amlexanox oral paste, a new treatment for recurrent minor aphthous ulcers I: Clinical demonstration of acceleration of healing and resolution of pain [J].Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 1997, 83(2): 222-230.
  • 5Atul Khandwaia; Richard G. Van Inwegen, Martha R. Charney, et al. 5% Amlexanox ral paste, a new treatment for recurrent minor aphthous ulcers II: Pharmacokinetics and demonstration of clinical safety [J]. Oral Surg Oral Med Oral Pathol, 1997, 83(2): 231-238.
  • 6周东新.口腔缓释粘附膜剂与粘附片剂的比较[J].现代中药研究与实践,2003,17(6):34-36. 被引量:7
  • 7中国药典[S].一部,2005:229

二级参考文献9

  • 1王本祥.现代中药药理学[M].天津:天津科学技术出版社,1999.941.
  • 2M Rosa Jimenez-Castellanos, et al. Mucoadhesive drug delivery systems. Drug Dev. Ind. Pharm. , 1993,19 (1&2)143.
  • 3BINNIE W H,CURRO F A,KHANDWALA A,et al.Amlexanox oral paste:a novel treatment that accelerates the healing of aphthous ulcers[J].Compend Contin Educ Dent,1997,18(11):1116-1120.
  • 4KHANDWALA A,VAN INWEGEN R G,ALFANO M C.5% Amlexanox oral paste,a new treatment for recurrent minor aphthous ulcers:Ⅰ.Clinical demonstration of acceleration of healing and resolution of pain[J].Oral Surg Oral Med Oral Pathol Oral Radiol Endod,1997,83 (2):222-230.
  • 5ZHENG J M.Transdermal Drug New Delivery Systems(经皮给药新剂型)[M].Beijing:People's Medical Publishing House,1997,256.
  • 6ATTIA M A,EL-GIBALY I,SHALTOUT S E,et al.Transbuccal permeation,anti-inflammatory activity and clinical efficacy of piroxicam formulated in different gels[J].Inter J Pharm,2004,276:11-18.
  • 7LU B.New Techniques and New Dosage Forms Drugs (药物新剂型与新技术)[M].Beijing:People' s Medical Publishing House.1998,358.
  • 8SHEN J M,WU Z Q.Drug Structure and Preperation(药物结构与制剂)[M].Beijing:Chinese Medicine and Technology Press.1989,163.
  • 9SCULLY C.Mucosal diseases series[J].Oral Dis,2005,11(2):57-67.

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