摘要
Hoxc13属于Hox(Homobox)基因家族Abd-B类成员之一,与毛囊形成和毛发生长密切相关。毛发结构蛋白KP(角蛋白)和KAP(角蛋白关联蛋白)的表达都受Hoxc13的严格调控,Hoxc13表达水平会直接影响毛发的特性,对维持毛囊的正常形态也至关重要。文章就Hoxc13的表达水平对毛囊发育和毛发生长的影响及Hoxc13与相关基因的调控进行了综述。
Hoxc13 belongs to the Abd-B class of Hox gene family, which participated in the hair follicle formation and hair growth regulation process. The structural protein of hair KP （keratin） and KAP （keratin-associated protein） expression is under regulation of Hoxc13, and then changes the characteristics of hair by regulating the composition of these two types of hair proteins and maintaining the normal morphology of hair follicle. In this review, we summarized that the relationship between the expression level of Hoxc13 and hair follicle development/hair growth and the mechanisim under the controling of Hoxc13 and relevant genes.
出处
《遗传》
CAS
CSCD
北大核心
2010年第7期656-662,共7页
Hereditas（Beijing)
基金
国家科技部项目(编号:2007AA10Z151
2007BAD56B03
30660122)资助
