摘要
目的:通过动物体内神经导管生物材料移植实验,观察、测定再生神经功能恢复的程度和神经再生的数目。方法:应用计算机检索中国期刊全文数据库1996/2010文献,检索词为"神经导管,神经损伤,导管材料,生物材料"。纳入有关神经导管材料在周围神经损伤修复中应用的动物实验。结果:现有的任何材料都不能制备出理想的神经导管。在生物可降解前提下,往往天然材料具有更好的生物相容性,而合成高聚物可以通过调节组分的比例和相对分子质量及相对分子质量分布等条件,从而调节降解时间和材料的机械性能以及物理性能。外周神经修复理想的导管首先需要选择合适的生物材料和组装技术,制成具有良好物理特性(通透性、柔韧性、降解性等)的导管,尤其是对于较大的神经缺损通透性和柔韧性更为重要。结论:在单腔中空导管中填充不同材料能促进神经的再生,联合应用几种不同的填充物质可能更加有利于神经修复。
OBJECTIVE：To observe and determine the degree of regenerated nerve functional recovery and the number of nerve regeneration in animal experiments of nerve conduit biomaterials transplantation.METHODS：A computer search was performed in the Chinese Journal Full-test database between 1996 and 2010,using key words of＂nerve conduit,nerve injury,conduit materials,biomaterials＂in Chinese.Animal experiments of the nerve conduit material in repair of peripheral nerve injury were included.RESULTS：Any of the existing materials are not sufficient to prepare ideal nerve conduit.Under the premise of the biodegradation,natural materials often have better biocompatibility,and synthetic polymers can regulate the degradation time,as well as mechanical and physical properties of the of materials through the modulation of the ratio of components,the molecular weight and molecular weight distribution.Ideal nerve conduit for peripheral nerve repair should select the appropriate biomaterials and assembly techniques,to prepare a conduit with good physical properties（permeability,flexibility,degradation and so on）,permeability and flexibility are more important for large nerve defects.CONCLUSION：The single-chamber hollow conduit filled various materials can promote neural regeneration,combination of several different filling materials may be more beneficial to nerve repair.
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2010年第29期5439-5442,共4页
Journal of Clinical Rehabilitative Tissue Engineering Research
