摘要
背景:组织工程心脏瓣膜有望克服生物瓣膜和机械瓣膜的缺点而从根本上解决瓣膜病外科面临的问题。其中,支架材料扮演着关键角色,而选择何种支架材料是经常困扰研究者的难题。目的:文章在强调细胞外基质与细胞的相互作用在组织动力学中有重要作用的基础上,对目前广泛使用的支架材料及其优缺点进行简要综述。方法:使用Pubmed文献检索数据库,采用医学主题词检索,检索词为"心脏瓣膜;组织工程",时间范围为2000-01/2009-08,语言限定为英文。共检索到186篇文章,其中综述34篇,实验研究152篇。选择文章主要内容与组织工程心脏瓣膜支架材料直接相关的、针对性强、代表性好、相关领域权威杂志的文章共39篇进行综述。结果与结论:天然支架材料因其优越的生物相容性和三维空间构象,具有其他材料不可比拟的仿生性。合成可降解高分子材料具有良好的可控性和力学性能也备受研究者青睐,而将天然材料和高分子材料融合一体构建的复合支架材料为组织工程心脏瓣膜的研究提供了新的策略和方向,具有广阔的应用前景。
BACKGROUND：Tissue engineered heart valves might bear promising surgical solutions of valvular heart disease for overcoming the limitations of biological and mechanical heart valve substitutes.Scaffolds play a central role in the tissue engineering.However,researchers often encounter an enormous variety of choices when selecting scaffolds for tissue engineered heart valves.OBJECTIVE：To highlight the role of extracellular matrix and its interactions with cells in tissue dynamics,and to review the major scaffolding materials which are used widely by describing their merits and disadvantages.METHODS：An online search of Pubmed database was performed using key words of＂heart valves,tissue engineering＂in Mesh for articles published between January 2000 and August 2009.A total of 186 literatures were screened out,including 34 reviews and 152 experimental studies.Among them,39 articles which were related to scaffolding materials of tissue engineered heart valve,published in authorized journal and considered to be a representative,were selected.RESULTS AND CONCLUSION：Natural scaffolds have inimitable biomimicry because of their good biocompatibility and three-dimensional microstructure compared to other materials.Synthetic degradable polymer materials have attracted the attention of researchers due to their well controllability,absorbability and biomechanical properties.The composite scaffold materials of synthetic polymer and natural materials are a potential alternative and has a promising application prospect.
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2010年第29期5471-5474,共4页
Journal of Clinical Rehabilitative Tissue Engineering Research
基金
国家自然科学基金(30872540)
国家863项目(2009AA03Z420)资助~~
