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小儿肺炎支原体肺炎的细胞免疫和流行病学分析 被引量:12

Cellullar immunity and epidemiologic analysis of pediatric patients with Mycoplasma pneumonia
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摘要 目的 探讨肺炎支原体肺炎的发病机理,特别是与机体免疫功能紊乱的关系。方法对90 例住院的支原体肺炎患儿,根据其 X 线肺部受侵程度,分为重症组和轻症组,并设立了对照组,分别检测了各组极期和恢复期的 T 细胞亚群、血清可溶性白细胞介素- 2 受体( S I L- 2 R) 及天然杀伤细胞( N K) 数。结果 肺炎支原体肺炎极期和恢复期 C D4 均下降, C D8 极期和恢复期均上升(t = 2 .63 ,2 .66 和2 .77 ,3 .36 , P< 0 .05) 。全部病人,无论极期还是恢复期 S I L- 2 R 均显著高于正常,而在病的极期变化尤为明显(t= 5 .26 ,3 .19 , P< 0 .01) 。检测还显示: S I L- 2 R 与病情有关,病情越重,增高越明显。结论 患支原体肺炎时存在细胞免疫功能紊乱,且检测 S I L- 2 R 的水平可作为监测其严重程度的指标。流行病学资料表明发病年龄以10 ~14 岁为多发。 Objective To understand the of immuno-reactions of pediatrics patients with Mycoplasma pneumonia. Methods 90 patients suffered from M.pneumonia were administered and divided into three groups:mild group, severe group, and normal control group. T cell subset parameters, natural killer cell and the serumsoluble interleukin-2 recepter of all of above were determined. Results Data showed:CD 4 decreased at both acute and recovery stage of M.pneumonia, while CD 8 remarkably increased ( t=2.63,2.66,2.77,3.36,P<0.05 ).SIL-2R level of all patients also greatly increased ( t= 5.26,3.19,P <0.01), especially in the serious group. Conclusion There are disturbances of cell- immune in M.pneumonia. The level of SIL-2R can serve as monitor on the degree of severeness of M.pneumonia. The incidence M.pneumonia appeared highest in the 10-14 year-old group.
出处 《中华流行病学杂志》 CAS CSCD 北大核心 1999年第1期47-49,共3页 Chinese Journal of Epidemiology
关键词 支原体肺炎 细胞免疫 肺炎 儿童 Mycoplasma pneumonia Celluler immunity Interleukin recepter
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