摘要
目的探讨黄芪醇提取物和水提取物对小鼠免疫功能的影响。方法分别用黄芪的水提取物和醇提取物给小鼠灌胃20d后,检测小鼠体质量、免疫器官重量、单核-腹腔巨噬细胞吞噬能力、淋巴细胞增殖转化的情况。结果黄芪低剂量组比高剂量组的胸腺指数大;高剂量混合组的单核-腹腔巨噬细胞吞噬能力强于低剂量混合组,且黄芪水提取组的吞噬能力强于醇提取组。黄芪对小鼠体质量、脾指数、脾淋巴细胞增殖转化作用的影响无统计学差异(P>0.05)。结论黄芪有增强免疫功能的作用;其水提取物的增强作用大于醇提取物。
Objective To study the effect of astragalus ethanol on immune function of mice.Methods One hundred mice were randomly divided into 10 groups（n=10）.Their body weight,immune organ weight,phagocytic function of mononuclear macrophages in abdominal cavity,proliferation and transformation of lymphocytes were detected 20 days after intra-gastric administration of astragalus ethanol extract.Results The thymus index was greater in single low-dose astragalus ethanol group than in single highdose astragalus ethanol group.The phagocytic function of mononuclear macrophages in abdominal cavity was stronger in mixed high-dose astragalus ethanol group than in mixed low-dose astragalus ethanol group.The phagocytic function of water astragalus extract was better than that of ethanol astragalus extract.No difference was found in body weight,spleen index,proliferation and transformation of lymphocytes（P0.05）.Conclusion Astragalus root can increase the immune function of mice and the ability of its water extract is stronger to increase the immune function of mice than that of its ethanol extract.
出处
《军医进修学院学报》
CAS
2010年第8期805-807,共3页
Academic Journal of Pla Postgraduate Medical School
基金
云南省中青年学术技术带头人后备人才培养基金(2006py057)
关键词
黄芪
免疫活性
小鼠
Astragalus Membranaceus
Immunocompetence
Mice
