摘要
目的:研究脑外伤后血清、脑脊液中髓鞘碱性蛋白(myelin basic protein,MBP)浓度变化,探讨该变化与脑损伤程度及预后情况的关系。方法:采用酶联免疫吸附法对65例脑外伤患者伤后24h、3d、7d血清及脑脊液中MBP浓度检测,并结合颅脑损伤程度和格拉斯哥预后计分(GOS)进行比较分析。结果:病例组患者血清和脑脊液中MBP含量升高程度与脑损伤程度及预后情况密切相关。结论:血清、脑脊液MBP对于判断脑外伤程度和预后情况具有较高的特异性和敏感性,可作为脑外伤治疗及病情转归的重要客观依据。
Objective：To evaluate the clinical significance of changes of myelin basic protein（MBP） levels in serum and cerebral spinal fluid（CSF） in patients with brain injury.Methods：MBP levels in serum and CSF were measured by enzyme linked immunosorbent assay in 65 patients with brain injury within 24h,on the third day and the seventh day after injured.The relationship between the MBP levels and GCS score were analyzed.Results：MBP concentrations in serum and cerebrospinal fluid were positively related to the injury severity and prognosis.Conclusion：The MBP concentration level of serum and cerebrospinal fluid is a specific and sensitive index for diagnosis of traumatic brain injury severity and for prognosis,and it can be used as an important objective reference for treatment and prognosis of brain injury.
出处
《现代生物医学进展》
CAS
2010年第13期2545-2548,共4页
Progress in Modern Biomedicine
基金
深圳市科技计划项目(200803231)
深圳市宝安区科技计划项目(2008174)
关键词
髓鞘碱性蛋白
颅脑损伤
预后
Myelin basic protein
Brain injure
Prognosis
