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101例胃肠间质瘤的病理特征及其预后分析 被引量:5

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摘要 目的 探讨胃肠间质瘤(GIST)的病理特征和影响预后的因素.方法 回顾性分析山西省肿瘤医院2002年1月到2008年12月收治的101例GIST患者的病理资料.结果 本组胃50例(49.5%),小肠19例(18.8%),其他部位32例(31.7%).核分裂像中位数18个/50 HPF.90例(89.1%)患者CD117阳性.1、3、5年生存率分别为75%、62%和57%.单因素分析显示,GIST细胞丰富程度对生存率的影响差异有统计学意义(x2=7.167,P=0.028).Cox回归分析结果提示,细胞密集(P=0.003)和肿瘤直径大于10 cm(P=0.028)预后差.结论 GIST细胞丰富程度和肿瘤大小是影响患者预后的重要因素.
出处 《中华胃肠外科杂志》 CAS 北大核心 2010年第7期536-537,共2页 Chinese Journal of Gastrointestinal Surgery
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参考文献8

  • 1Miettinen M,Sarlomo-Rik ala M,Lasota J.Gastrointestinal stromal tumours.Ann Chir Gynaecol,1998,87(4):278-281.
  • 2Miettinen M,El-Rifai W,H L Sobin L,et al.Evaluation of malignancy and prognosis of gastrointestinal stromal tumors:a review.Hum Pathol,2002,33(5):478-483.
  • 3Yan H,Marchettini P,Acherman YI,et al.Prognostic assessment of gastrointestinal stromal tumor.Am J Clin Oncol,2003,26(3):221-228.
  • 4Steigen SE,Eide TJ.Gastrointestinal stromal tumors (GISTs):a review.APMIS,2009,117(2):73-86.
  • 5Miettinen M,Lasota J.Gastrointestinal stromal tumors:review on morphology,molecular pathology,prognosis,and differential diagnosis.Arch Pathol Lab Med,2006,130(10):1466-1478.
  • 6Dematteo RP,Gold JS,Saran L,et al.Tumor mitotic rate,size,and location independently predict recurrence after resection of primary gastrointestinal stromal tumor (GIST).Cancer,2008,112(3):608-615.
  • 7张云,曹晖,汪明,沈丹平,沈志勇,倪醒之,吴志勇,沈艳莹,刘强.181例胃肠间质瘤的临床病理及预后分析[J].中华胃肠外科杂志,2009,12(2):150-154. 被引量:19
  • 8Casali PG,Jost L,Reichardt P,et al.Gastrointestinal stromal tumours:ESMO clinical recommendations for diagnosis,treatment and follow-up.Ann Oncol,2009,20 Suppl 4:64-67.

二级参考文献12

  • 1詹文华,王鹏志,邵永孚,伍晓汀,顾晋,李荣,万德森,丁克峰,师英强,于吉人,卢辉山,邹小明,毕建威,孙益红,陆云飞,陈道达,张信华.伊马替尼术后辅助治疗胃肠间质瘤的多中心前瞻性临床试验中期报告[J].中华胃肠外科杂志,2006,9(5):383-387. 被引量:85
  • 2张信华,何裕隆,詹文华,蔡世荣,张常华.胃肠间质瘤135例临床诊治分析[J].中华胃肠外科杂志,2007,10(1):17-20. 被引量:38
  • 3Fletcher CD, Beman JJ, Corless C, et al. Diagnosis of gastrointestinal stromal tumors: a consensus approach. Hum Pathol, 2002, 33(5):459-465.
  • 4Kamiyama Y, Aihara R, Nakabayashi T, et al. ^18F- fluorodeoxyglucose position emission tomography: useful technique for predicting malignant potential of gastrointestinal stromal tumors. World J Surg, 2005, 29(11) : 1429-1435.
  • 5Trent JC, Benjamin RS. New developments in gastrointestinal stromal tumor. Curr Opin Oncol, 2006, 18(4):386-395.
  • 6Miettinen M, Sobin LH, Lasota L. Gastrointestinal stromal tumors of stomach : a clinicopathologic, immunohistochemical, and molecular genetic study of 1765 cases with long-term follow-up. Am J Surg Pathol, 2005, 29(1 ) :52-68.
  • 7Heinrich MC, Corless CL, Duensing A, et al. PDGFRA activating mutations in gastrointestinal stromal tumors. Science, 2003, 299(5607) :708-710.
  • 8Gold JS, Dematteo RP. Combined surgical and molecular therapy: the gastrointestinal stromal tumor model. Ann Surg, 2006, 244(2) : 176-184.
  • 9Clary BM, DeMatteo RP, Lewis JJ, et al. Gastrointestinal stromal tumors and leiomyosarcoma of the abdomen and retroperitoneum: a clinical comparison. Ann Surg Oncol, 2001,8(4):290-299.
  • 10An JY, Choi MG, Noh JH, et al. Gastric GIST:a single institutional retrospective experience with surgical treatment for primary disease. Eur J Surg Oncol, 2007, 33(8) : 1030-1035.

共引文献18

同被引文献62

  • 1周海宁,陈申思,李博.97例胃肠间质瘤临床分析[J].宁夏医科大学学报,2013,35(10):1137-1139. 被引量:1
  • 2詹文华,王鹏志,邵永孚,伍晓汀,顾晋,李荣,万德森,丁克峰,师英强,于吉人,卢辉山,邹小明,毕建威,孙益红,陆云飞,陈道达,张信华.伊马替尼术后辅助治疗胃肠间质瘤的多中心前瞻性临床试验中期报告[J].中华胃肠外科杂志,2006,9(5):383-387. 被引量:85
  • 3Corless CL,Heinrich MC.Molecular pathobiology of gastrointestinal stromal sarcomas[J].Annu Rev Pathol,2008,3:557-586.
  • 4Nilsson B,Bumming P,Meis-Kindblom JM,et al.Gastrointestinal stromal tumors:the incidence,prevalence,clinical course,and prognostication in the preimatinib mesylate era-a population-based study in western Sweden[J].Cancer,2005,103:821-829.
  • 5Lux ML,Rubin BP,Biase TL,et al.KIT extracellular and kinase domain mutations in gastrointestinal stromal tumors[J].Am J Pathol,2000,156:791-795.
  • 6Heinrich MC,Corless CL,Duensing A,et al.PDGFRA activating mutations in gastrointestinal stromal tumors[J].Science,2003,299:708-710.
  • 7DeMatteo RP,Lewis JJ,Leung D,et al.Two hundred gastrointestinal stromal tumors:recurrence patterns and prognostic factors for survival[J].Ann Surg,2000,231:51-58.
  • 8Rossi CR,Mocellin S,Mencarelli R,et al.Gastrointestinal stromal tumors:from a surgical to a molecular approach[J].Int J Cancer,2003,107:171-176.
  • 9Joensuu H.Risk stratification of patients diagnosed with gastrointestinal stromal tumor[J].Hum Pathol,2008,39:1411-1419.
  • 10Andersson J,Bumming P,Meis-Kindblom JM,et al.Gastrointestinal stromal tumors with KIT exon 11 deletions are associated with poor prognosis[J].Gastroenterology,2006,130:1573-1581.

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