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清开灵与地塞米松磷酸钠注射液的配伍稳定性考察

Study on stability of compatibility of Qingkailing and Dexamethasone Sodium Phosphate Injection
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摘要 目的 考察清开灵注射液、清开灵合地塞米松磷酸钠注射液在0.9%氯化钠注射液、5%葡萄糖注射液、10%葡萄糖注射液、葡萄糖氯化钠注射液中配伍的稳定性.方法 观察清开灵注射液、清开灵合地塞米松磷酸钠注射液溶于0.9%氯化钠注射液、5%葡萄糖注射液、10%葡萄糖注射液、葡萄糖氯化钠注射液配伍后于室温放置8 h内的外观、pH及不溶性微粒的变化.结果 地塞米松磷酸钠不影响清开灵的稳定性,与4种溶液配伍后的pH值均在6.4~7.0,配伍液外观无明显变化,按<中国药典>的要求检测不溶性微粒的限值,均符合规定.结论 清开灵注射液、清开灵合地塞米松磷酸钠注射液适以0.9%氯化钠注射液、5%葡萄糖注射液、10%葡萄糖注射液、葡萄糖氯化钠注射液作溶媒配伍于8 h内使用. Objective To study the stability of Qingkailing injection, Qingkailing and dexamethasone sodium phosphate injection in compatibility of 0.9% sodium chloride injection, 5% glucose injection, 10% glucose injection, glucose and sodium chloride injection. Methods Such changes as appearance, pH, and insoluble particulate were observed at the room temperature after mixing together of the Qing Kai Ling Injection, Qingkailing and dexamethasone sodium phosphate injection with 0.9% sodium chloride injection, 5% glucose injection, 10% glucose injection, glucose and sodium chloride injection. Results Dexamethasone sodium phosphate did not affect the stability of the Qingkailing. The PH value of Qingkailing stayed at 6.4~7.0 after being mixed with four kinds of solutions. The compatibility solutions had no significant change in appearance, met to the requirements of the Chinese Pharmacopoeia insoluble particle detection specification Conclusion Qing Kai Ling Injection, Qing Kai Ling and dexamethasone sodium phosphate injection can be used together with solvent compatibility of 0.9% sodium chloride injection, 5% glucose injection, 10% glucose injection, glucose and sodium chloride injection within 8 h.
出处 《国际中医中药杂志》 2010年第4期357-358,共2页 International Journal of Traditional Chinese Medicine
关键词 清开灵注射液 地塞米松磷酸钠注射液 PH 不溶性微粒 稳定性 Qingkailing Injection Dexamethasone Sodium Phosphate Injection pH Stability of insoluble particles
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