摘要
目的用三氧化二砷（Ａｓ２Ｏ３）及全反式维甲酸（ＲＡ）治疗急性早幼粒细胞白血病（ＡＰＬ）７５例，进行临床疗效的对比分析。方法随机分ＡＰＬ患者３７例及３８例两组，临床观察三氧化二砷，全反式维甲酸对ＡＰＬ的缓解率，无病生存期及其毒副作用。结果Ａｓ２Ｏ３组、ＲＡ组的完全缓解（ＣＲ）率分别为８６４％及８４２％（Ｐ＞００５）；两组缓解期及无病生存期亦无显著差异，且Ａｓ２Ｏ３治疗剂量的毒副作用小，均为可逆性。结论Ａｓ２Ｏ３能诱导细胞凋亡，与ＲＡ无交叉耐药性，是疗效可靠、应用安全的又一种新的诱导分化剂。
Objective To compare the therapeutic effects and reactions of intravenous arsenic trioxide and all trans retinoic acid in treating patients with acute promyelocytic leukemia (APL). Methods 75 cases of APL were randomized either to arsenic trioxide (37) or to all trans retinoic acid (38). The rates of complete remission (CR), disease free survival (DFS) and side effects were observed. Results In the two groups of patients with APL, the rate of CR was 86.4% and 84.2%. There was also no significant difference in the rate of DSF phase of CR ( P >0.05). The side effects of these two medications in therapeutic dose were mild and there was no cross resistance between them. Conclusion Arsenic trioxide can lead to apoptosis of leukemic cells and might be a new promising drug to induce differentiation.
出处
《中华内科杂志》
CAS
CSCD
北大核心
1999年第2期113-115,共3页
Chinese Journal of Internal Medicine
