摘要
目的:探讨类风湿关节炎(RA)骨侵蚀与抗环瓜氨酸肽抗体(抗CCP抗体)的相关性。方法:通过测定血清抗CCP抗体将112名RA患者分成抗CCP抗体阳性组与阴性组,于治疗前后分别计算X片中骨侵蚀Sharp评分及疾病活动度DAS28评分,对两组之间差异进行统计分析。结果:抗CCP抗体阳性组64例,Sharp评分在治疗前后分别为0.135±0.224,1.216±2.228;抗CCP抗体阴性组48例,Sharp评分在治疗前后分别为0.108±0.273,0.562±1.244。抗CCP抗体阳性组DAS28评分在治疗前后分别为4.216±1.228,2.714±1.761,抗CCP抗体阴性组DAS28评分在治疗前后分别为4.114±1.651,2.505±1.841,治疗后两组Sharp评分差异有统计学意义,阳性组大于阴性组;而治疗后两组DAS28评分差异无统计学意义。结论:抗CCP抗体与X线提示的RA骨侵蚀有相关性。
Objective： To explore the relationship between antieyelie citrullinated peptide antibody （anti-CCP antibody）and erosion of bone in rheumatoid arthritis. Methods： The data of 112 patients with RA were analyzed, including radiographic damage of hands （ Sharp grades） and anti-CCP in serum. Results. All patients were classified into anti-CCP positive group and anti-CCP negative group. The initial Sharp＇s grades of anti-CCP positive group including 64 patients were 0. 135 ±0. 224 and arrived at 1. 216 ±2. 228 two years later. Comparatively, the initial and 2 years later Sharp＇s grades of anti-CCP negative group including 48 patients were 0. 108 ±0. 273 and 0. 562 ±1. 244 respectively. The DAS28＇s score of anti-CCP positive group was 4. 216 ±1. 228 initially and changed to 2. 714 ±1. 761 two years later. The DAS28＇s score of anti-CCP negative group declined from 4. 114 ±1. 651 to 2. 505 ±1. 841. Conclusion： The existence of anti-CCP antibody was associated with severity of erosion of bones in patients with RA.
出处
《江苏大学学报（医学版）》
CAS
2010年第4期324-326,共3页
Journal of Jiangsu University：Medicine Edition
关键词
类风湿关节炎
骨侵蚀
抗环瓜氨酸肽抗体
Sharp评分
rheumatoid arthritis
erosion of bones
anti-cyclic citrullinated peptide antibody
Sharp grades
