摘要
目的:观察糖皮质激素和环磷酰胺联合治疗活动性浸润性突眼的临床疗效,以便为浸润性突眼的治疗找到更好的方法。方法:选择12例符合活动性浸润性窦眼的甲亢患者,在用丙基硫氧嘧啶治疗甲亢的同时,对其突眼进行醋酸泼尼松16周和环磷酰胺8周的联合治疗;而对照组为甲亢伴活动性浸润性突眼病例,因依从性低,不愿意接受醋酸泼尼松及环磷酰胺治疗,只治疗甲亢。观察患者各项眼征的变化情况。结果:与对照组相比,治疗组有效率达到80%～90%,经统计学处理,证明治疗与否差异有高度统计学意义(P<0.01);而其副作用控制在患者能够耐受的限度以内。结论:进行醋酸泼尼松和环磷酰胺的口服联合治疗是一种有效的治疗方法。
Objective：To observe Corticosteroids and Cyclophosphamide combination therapy for active invasive prominent eyes,so as to observe the clinical curative effect of invasive prominent eyes to find better methods of treatment.Methods：In 12 cases with active invasive prominent eyes in patients with hyperthyroidism,the eye with Propylthiouracil treat hyperthyroidism,their invasive prominent eyes on Acetic Acid Prednisone 16 weeks and Cyclophosphamide 8 weeks of combination therapy.The control group treated only hyperthyroidism.The eyes of the patients were observed.Results：Compared with control group,the treatment efficiency reached 80%-90% by statistical processing,proved that there were significant differences after treatment（P〈0.01）.The effects of tolerance in patients can be controlled within the limit.Conclusion：At present for hyperthyroidism invasive prominent eyes no special superior treatment method,Acetic Acid Prednisone and Cyclophosphamide oral combination therapy is still a kind of effective,convenient and economical method,apply the universality of the treatment.
出处
《中国医药导报》
CAS
2010年第22期19-21,共3页
China Medical Herald
关键词
活动性浸润性突眼
甲亢
醋酸泼尼松
环磷酰胺
Active invasive prominent eyes
Hyperthyroidism
Acetic Acid Prednisolone
Cyclophosphamide
