摘要
目的:观察伍用小剂量纳洛酮用于术后镇痛的效果。方法:选择ASAⅠ～Ⅱ级行下腹部择期手术后中度以上疼痛的患者60例,随机分为M组和N组。M组镇痛泵液配方为吗啡10.00μg/(kg·h)加入生理盐水稀释至100ml。N组镇痛泵液配方在M组基础上加入纳洛酮0.25μg/(kg·h)。记录启动PCA泵后两组患者VSA评分,有效按压次数/实际按压次数比(D1/D2),记录恶心、呕吐的次数及镇静评分。结果:两组VSA评分、D1/D2在8、12h的时段内差异有统计学意义(P<0.05)。两组在4、8、12h的时段内恶心、呕吐的次数及镇静评分差异均有统计学意义(均P<0.05)。结论:伍用小剂量纳洛酮用于术后镇痛,能增加吗啡术后镇痛的效果,降低吗啡的耐受性和依赖性以及恶心、呕吐等副作用的发生率。
Objective：To assess the effects of postoperative analgesia with lowdose Naloxone for the patients.Methods：60 cases scheduled for selective hypogastrium surgery who received a standardized general anesthesia with ASA Ⅰ-Ⅱ were randomly divided into M and N groups.The patients in group M received the mixture of Morphine 10.00 μg/（kg·h） and 0.9% Normal saline all together 100 ml and the patients in group N received combine with Naloxone 0.25 μg/（kg·h）.The effects of analgesia after operation were assessed by visual analogue scale（VAS）,Ramsey sedation scores and the rate of nausea,vomiting and the patients＇ satisfaction with the analgesia device,the proportion of the frequency of pressing bolus by the patient（D1） and the frequency of bolus dose delivered（D2）.Results：There were significance differences between two groups in VSA and D1/D2 of 8 h and 12 h,also in Ramssy sedation scores and the rate of nausea,vomiting of 4,8,12 h.Conclusion：Lowdose Naloxone and Morphine used for postoperative analgesia enhance the analgesic effect of morphine and significantly reduce the rate of nausea and vomiting.
出处
《中国医药导报》
CAS
2010年第22期117-118,共2页
China Medical Herald
关键词
小剂量纳洛酮
术后镇痛
吗啡
Lowdose Naloxone
Postoperative analgesia
Morphine
