期刊文献+

肺癌患者血清CEA、CYFRA21-1和NSE的检测及临床意义 被引量:4

Detection and clinical significance of serum CEA,CYFRA21-1 and NSE in patients with lung cancer
原文传递
导出
摘要 目的探讨外周血癌胚抗原(CEA)、细胞角蛋白19片段(CYFRA21-1)和神经元特异性烯醇化酶(NSE)的检测对肺癌的诊断、病理分型和疗效判断的临床用价值。方法采用化学发光法检测了62例肺癌患者、54例良性肺部疾病患者、36例健康人、40例肺癌患者手术前后血清CEA、CYFRA21-1和NSE的水平。结果肺癌患者手术前血清CEA、CYFRA21-1和NSE的含量明显高于良性肺部疾病组及正常对照组(P<0.01)。鳞癌组、腺癌组和小细胞癌组之间肿瘤标志物CEA、CYFRA21-1和NSE水平差异有统计学意义。CEA阳性率以腺癌组最高(84%),CYFRA21-1阳性率以鳞癌组最高(85.2%),NSE阳性率以小细胞癌组最高(80.0%)。手术治疗后未复发转移组CEA、CYFRA21-1和NSE水平低于术前,而复发转移组与术前比变化不显著(P>0.05)。结论血清CEA、CYFRA21-1和NSE的检测对不同病理类型肺癌患者的诊断、病情检测及疗效判断有较好的临床参考价值。 Objective To investigate the value of detection of serum CEA,CYFRA21-1 and NSE to the diagnosis,pathological classification and therapeutic efficiency of lung carcinoma.Method Serum CEA,CYFRA21-1 and NSE were measured with chemilum inescence immunoassay in 62 cases of lung cancer,54 cases of benign pulmonary disease,36 cases of healthy controls and 40 cases of lung cancer before and after surgery.Result The levels of CEA,CYFRA21-1 and NSE in patients with lung carcinoma before surgery were higher than those in patients with benign pulmonary diseases and healthy controls(P 0.01).Single analysis showed that the highest positive rates of CEA,CYFRA21-1 and NSE were seen in adenocarcinoma,squamous carcinoma and small cell lung cancer,respectively;the serum levels were decreased than those before surgery in the non-recurrence group,but increased or remained unchanged in the recurrence group.Conclusion Measurement of CEA,CYFRA21-1 and NSE in serum provides useful information for diagnosis,monitoring and effects assessment of the chemotherapy of lung cancer with different pathological types.
出处 《中国微生态学杂志》 CAS CSCD 2010年第7期643-645,共3页 Chinese Journal of Microecology
关键词 肺癌 癌胚抗原 细胞角蛋白19片段 神经元特异性烯醇化酶 肿瘤标志物应 Lung cancer CEA CYFRA21-1 NSE Tumor markers
  • 相关文献

参考文献18

  • 1JEMAL A, TWAEIR C, MURRAY T, et al. Cancer statistics [ J ]. CA Cancer J Clin ,2004,54( 1 ) :92-119.
  • 2GOLD P, FREEDMAN S O. Demonstration of tumor specific antigen in human colonic carcinoma by immunologic to tolerance and absorption techniques[J]. Exp Med,1965,127(8) :439-462.
  • 3宋丽华,宋现让,张锡芹,齐洁琳,张品良,刘美芹,田禾,刘蒲香.进展期肺癌肿瘤标记物临床应用价值[J].肿瘤防治杂志,2003,10(3):272-275. 被引量:19
  • 4MATSUOKA K, SUMITOMO S, NAKASHIMA N, et al. Prognostic value of carcinocmbryonic antigen and CYFRA21-1 in patients with pathological stage I non-small lung cancer[ J]. Eur I Cardiothomc Surg,2007,32 (3) :435-439.
  • 5ANDO S, KIMURA H, LWAI N, et al. Optimal combination of seven tumor markers in prediction of advanced stage at fist examination of patients with non-small cell lung cancer[ J]. Anticancer Ros, 2001,21 (4B) :3085-3092.
  • 6朱亚林,朱湘平.CEA,CYFRA21-1和NSE联检在肺癌诊治中的应用[J].放射免疫学杂志,2004,17(6):427-429. 被引量:26
  • 7ALATAS F, ALATAS O, METINTAS M. Diagnostic value of CEA, CA15-3 ,CA19-9 ,CYFRA21-1 ,NSE and TSA assay inpleural effusions [J]. Lung cancer,2001,31 ( 1 ) :9.
  • 8KOGA H, EQUCHI K, SHINKAI T, et al. Preliminary evaluation of the new tumor marker, CYFRA21-1 ,in lung cancer patients[ J ]. Jpn J Clin Oncol, 1994,24 ( 5 ) : 263.
  • 9SCHNEIDER J,PHILIPP M, VELCOVSKY H G,et al. Pro-gastrin- releasing peptide (Pro GRP), neuron specific enolase (NSE), careinoembryonic antigen (CEA) and eytokeratin 19-fragments (CYFRA21- 1 ) in patients with lung cancer in comparison to other lung diseases [ J ]. Anticancer Res,2003,23 (2A) : 885-893.
  • 10KUIPA J, WOJCIK E, REINFUSS M, et al. Carcinoembryonie antigen, squamous cell carcinoma antigen, CYFRA21-1, and neuron-specific enolase in squamous cell lung cancer patients[ J]. Clin Chem ,2002,48 (11) :1931-1933.

二级参考文献23

  • 1桂霞,刘诚明,谌宏鸣.CA125和CYFRA21-1测定对肺癌的诊断价值[J].新疆医科大学学报,2004,27(3):283-284. 被引量:5
  • 2左志通,凌春华,刘皓,郑世营.血清TSGF、CYFRA21-1和NSE联合检测对肺癌的诊断价值[J].苏州大学学报(医学版),2005,25(2):265-267. 被引量:10
  • 3[1]Cooper EH.Neuron-specific enolase[J].Int J Biol Markers,1994,9(4):205-210.
  • 4[2]Niklinski J,Furman M,Chyczewska E,et al.Diagnostic and prognostic value of the new tumour marker CYFRA 21-1 in patients with squamous cell lung cancer[J].Eur Respir J,1995,8(2):291-294.
  • 5[3]Maeda Y,Segawa Y,Takigawa N,et al.Clinical usefulness of serum cytokeratin 19 fragment as a tumor marker for lung cancer[J].Intern Med,1996,35(10):764-771.
  • 6[4]Mitsuhashi N,Takahashi T,Sakurai H,et al.Establishment and characterization of a new human lung poorly differentiated adenocarcinoma cell line,GLL-1,producing carcinoembryonic antigen (CEA) and CA19-9[J].Lung Cancer,1995,12(1-2):13-24.
  • 7[5]Diez M,Gomez A,Hernando F,et al.Serum CEA,CA125,and SCC antigens and tumor recurrence in resectable non-small cell lung cancer[J].Int J Biol Markers,1995,10(1):5-10.
  • 8[6]Pujol JL,Grenier J,Parrat E,et al.Cytokeratins as serum markers in lung cancer:a comparison of CYFRA 21-1 and TPS[J].Am J Respir Crit Care Med, 1996,154(3 Pt 1):725-733.
  • 9[7]Van de Pol M,Twijnstra A,ten Velde GP,et al.Neuron-specific enolase as a marker of brain metastasis in patients with small-cell lung carcinoma[J].J Neurooncol,1994,19(2):149-154.
  • 10Karnak D, Ulubay G, Kayncan O, Beder S, Ibis E, Oflaz G. Evaluation of Cyfra 21-1 : a potential tumor marker for non-small cell lung carcinomas. Lung 2001 ; 179( 1 ):57-65.

共引文献71

同被引文献28

  • 1吴健民.对肿瘤标志物的再认识[J].中华检验医学杂志,2005,28(1):11-13. 被引量:116
  • 2周善良,胡相起,金德芹.CYFRA21-1、NSE、SA联合检测诊断肺癌的实验研究[J].医学检验与临床,2006,18(2):26-28. 被引量:1
  • 3张小红,王静,王红民.血清NSE TSGF CA125 CYFRA21_1联合检测对肺癌的诊断价值[J].肿瘤基础与临床,2006,19(1):16-18. 被引量:29
  • 4张青云.肿瘤标志物临床检测技术现状及发展趋势[J].中华检验医学杂志,2006,29(7):585-589. 被引量:29
  • 5Schneider J. Tumor markers in detection of lung cancer [J]. Advclinchem, 2006,42 : 1-41.
  • 6Oremek GM, Sauer-eppel H, Bruzdziak TH. Value of tumor and inflammatorymarkers in lung cancer[J]. An- ticancer Res, 2007, 27..1911-1915.
  • 7Cho WC. Potentially useful biomarkers {or the diagno- sis, treatment and prognosis of lung cancer[J]. Biomed Pharmacother, 2007,61 .. 515-519.
  • 8Hatkazis KD, Froudarakis ME, Bouros D, et al. Prog- nostic value of serum tumor markers in patients with lung cancer rJ]. Respiration, 2002,69:25-29.
  • 9Ebert W, Muley T, Trainer R, et al. Comparision of changes in the NSE levels with clinical assessment in the therapy monitoring of patients with small cell lung eaneer[J']. Antieaneer RES,2002,22(8): 1083.
  • 10Plavec G, Ninkovic M, Kozlovacki G, et al. Tumor markers in pleural effusions inbronchoginic carcinoma and tuberculosis[J]. Vojnosanit Pregl, 2002,59 (1).- 23.

引证文献4

二级引证文献10

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部